Training in Translational Lung Research

转化肺研究培训

• 批准号: 7213384
• 负责人: Neil W. Schluger
• 金额: $ 24.74万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7213384
• 关键词: Lung; Research; Training

DESCRIPTION (provided by applicant): Progress in pulmonary medicine in several areas has been limited by an incomplete understanding of basic mechanisms of the pathogenesis of disorders such as chronic obstructive pulmonary disease (COPD), asthma, acute lung injury and the adult respiratory distress syndrome, tuberculosis, interstitial lung disease (including idiopathic pulmonary fibrosis), and lung cancer. In the past few years however, advances in basic science have brought a greater understanding of some of the processes likely to be involved in these diseases, and advances in basic investigative techniques such as genomics and proteomics, hold promise for broad application in clinical medicine. Crucial to the application of advances in basic science to important problems in clinical pulmonary medicine will be the development of a cadre of physician-scientists with an both an understanding of relevant basic science and lung biology as well as the tools to apply that knowledge in the clinical setting in order to carry our rigorous translational studies in lung disease that can test and confirm hypotheses developed at the bench, with the ultimate goal of developing potent new therapeutic approaches for a variety of disorders. Our goal in this application is consistent with that set forth by NIH itself in its introduction of career development awards for young investigators with an interest in clinical or patient oriented research: "to encourage research-oriented clinicians to develop independent research skills and gain experience in advanced methods and experimental approaches needed to conduct patient-oriented research." The training program described in this application will enable trainees to successfully apply for these NIH-sponsored career development awards, or their equivalent. The rationale behind the establishment of this training program is a follows: 1. There is a manifest need to prepare physician-scientists to conduct translational research in pulmonary medicine. 2. As basic science research reaches this translational stage, it will be important to Wain individuals to develop an integrated understanding of a variety of processes in cell biology, immunology, genetics, molecular biology, clinical research, epidemiology, and clinical medicine. 3. The College of Physicians and Surgeons of Columbia University and the Columbia Presbyterian Medical Center provide an outstanding environment for a comprehensive and integrated training program in pulmonary translational research, owing to the depth and breadth of basic and clinical academic programs at the institutions. 4. By providing formal didactic instruction, mentoring, and well-structured research opportunities, the program will attract basic and clinical scientist trainees who wish to receive rigorous training in the area of pulmonary translational research.

描述（由申请人提供）： 由于对慢性阻塞性肺病（COPD）、哮喘、急性肺损伤和成人呼吸窘迫综合征、结核病、间质性肺疾病等疾病发病机制的基本了解不完全，限制了肺医学在多个领域的进展。包括特发性肺纤维化）和肺癌。 然而，在过去几年中，基础科学的进步使人们对这些疾病可能涉及的一些过程有了更深入的了解，并且基因组学和蛋白质组学等基础研究技术的进步有望在临床医学中得到广泛应用。 将基础科学的进步应用于临床肺医学的重要问题将至关重要的是培养一支既了解相关基础科学和肺生物学又了解将这些知识应用于临床肺医学的工具的医师科学家队伍。临床环境，以便对肺部疾病进行严格的转化研究，可以测试和证实在实验室中提出的假设，最终目标是为各种疾病开发有效的新治疗方法。 我们在此申请中的目标与 NIH 本身在为对临床或以患者为导向的研究感兴趣的年轻研究人员引入职业发展奖时提出的目标是一致的：“鼓励以研究为导向的临床医生发展独立研究技能并获得以下方面的经验：进行以患者为导向的研究所需的先进方法和实验方法。” 本申请中描述的培训计划将使学员能够成功申请这些 NIH 赞助的职业发展奖项或同等奖项。 制定本培训计划的理由如下： 1. 显然需要培养医师科学家来开展肺医学转化研究。 2. 随着基础科学研究达到这一转化阶段，对 Wain 个人来说，对细胞生物学、免疫学、遗传学、分子生物学、临床研究、流行病学和临床医学的各种过程进行综合理解将非常重要。 3. 哥伦比亚大学内科医生和外科医生学院和哥伦比亚长老会医学中心由于其基础和临床学术课程的深度和广度，为肺部转化研究的全面综合培训课程提供了良好的环境。 4. 通过提供正式的教学指导、指导和结构良好的研究机会，该计划将吸引希望在肺部转化研究领域接受严格培训的基础和临床科学家学员。