Core--Community Outreach and Translation

核心——社区外展和翻译

• 批准号: 7173284
• 负责人: CHRISTIE DREW
• 金额: $ 7.16万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7173284
• 关键词: air sampling /monitoring; biomedical facility; children; community health services; environmental contamination; environmental exposure; environmental health; environmental protection; health education; health services research tag; human subject; information dissemination; medical outreach /case finding; organophosphorus insecticide; pesticide biological effect; public health

DESCRIPTION (provided by applicant) The theme of the Center for Child Environmental Health Risks Research is: Working to understand the mechanisms (molecular, genetic, age, exposure and social factors) that define children 's susceptibility to pesticides, identifying the implications of this susceptibility for development and learning, and partnering with the communities to translate our findings into risk communication, risk management and prevention strategies. Consistent with the objectives of the RFA, the investigators have designed a multi-disciplinary research program including members from multiple institutions, schools, departments, and disciplines to facilitate both basic and applied research aimed at reducing the adverse effects of environmental pesticide exposures in children. This research program includes basic mechanistic studies of toxicity, exposure, assessment, and community intervention. For the Community Intervention Study, they have partnered with the Yakima Valley community, located in the agricultural center of Washington State to jointly sponsor a program aimed at reducing childhood pesticide exposure. The facility cores support this research program and put these projects into a child specific risk assessment context so that the investigators' scientific findings on pesticide toxicity and exposure can be translated to directly improve the risk assessment models they design, making the models protective of children 's health. These projects are responsive to two of the three specific research foci identified in RFA ES-03404, which are particularly related to the Mission Areas of U.S. EPA and NIGHS. These two topics are childhood neurodevelopment and learning, and exposures of interest.

描述（由申请人提供） 儿童环境健康风险中心研究的主题是：努力​​了解定义儿童对农药的易感性的机制（分子，遗传，年龄，暴露和社会因素），确定这种敏感性对发展和学习的影响，并与社区合作将我们的发现转化为风险交流，风险交流和预测策略。 与RFA的目标一致，研究人员设计了一项多学科研究计划，包括来自多个机构，学校，部门和学科的成员，以促进旨在减少儿童环境农药暴露的不利影响的基础和应用研究。 该研究计划包括有关毒性，暴露，评估和社区干预的基本机理研究。 在社区干预研究中，他们与位于华盛顿州农业中心的亚基马山谷社区合作，共同赞助了一项旨在减少儿童农药暴露的计划。 该设施核心支持该研究计划，并将这些项目置于儿童特定风险评估环境中，以便可以将研究人员对农药毒性和暴露的科学发现进行转化，以直接改善其设计的风险评估模型，从而使这些模型保护儿童健康。 这些项目对RFA ES-03404中确定的三个特定研究焦点中的两个响应，这与美国EPA和NIGH的任务领域特别相关。这两个主题是童年的神经发育和学习以及感兴趣的暴露。