Soft Tissue Biomechanical Behavior During Acupuncture in Low Back Pain

针灸治疗腰痛期间的软组织生物力学行为

• 批准号: 7289874
• 负责人: HELENE M LANGEVIN
• 金额: $ 36.9万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7289874
• 关键词: 3-Dimensional; Abbreviations; Acupuncture Points; Acupuncture Therapy; Acupuncture procedure; Alternative Medicine; Appendix; Back; Behavior; Biomechanics; Bladder; Characteristics; Chronic; Clinical Trials; Condition; Connective Tissue; Data; Development; Disease; Engineering; Frequencies; Future; Gallbladder; Goals; Healed; Human; Image; Image Analysis; Imagery; Leg; Localized; Location; Low Back Pain; Mainstreaming; Measurement; Measures; Meridians; Modeling; Muscle; Nature; Needles; Neuronal Plasticity; Noise; One-Step dentin bonding system; Orthopedics; Other Therapy; Outcome Measure; Pain; Palpation; Patients; Pattern; Physics; Physiological; Process; Radio; Radiology Specialty; Range; Recurrent Low Back Pain; Research Personnel; Robotics; Role; Rotation; Series; Signal Transduction; Structure; Techniques; Testing; Thick; Time; Tissues; Torque; Ultrasonography; base; computerized; healing; human subject; improved; in vivo; multidisciplinary; programs; response; soft tissue; subcutaneous; theories

DESCRIPTION (provided by applicant): The goal of this proposal is to test the overall hypothesis that subjects with chronic or recurrent low back pain (LBP) have an abnormal soft tissue response to acupuncture needling, and that this altered response is associated with abnormal perimuscular connective tissue structure and biomechanics. We will also test whether or not altered needling responses in LBP are generalized, or localized to specific locations as predicted by traditional acupuncture theory. 80 LBP and 80 No-LBP subjects will undergo one testing session using computerized robotic acupuncture needling and ultrasound elastography. Needle torque, force and tissue displacement patterns will be compared in LBP vs. No-LBP at Meridians vs. Non-Meridians and Acupuncture Points vs. Non-Acupuncture Points in the back and leg (Aim 1). We also will evaluate soft tissue structural and biomechanical characteristics in the low back by measuring perimuscular connective tissue thickness, ultrasound signal to noise ratio, structural continuity and biomechanical parameters (stiffness and damping) (Aim 2). Accomplishing the Aims of this study will 1) advance our understanding of acupuncture mechanisms 2) provide a first step toward investigating a new dynamic pathophysiological model for LBP incorporating connective tissue and neuroplasticity and 3) provide objective outcome measures of connective tissue structure and biomechanics that can be used in future clinical trials of acupuncture and other therapies for LBP. Relevance: Despite its widespread use for the treatment low back pain (LBP), the mechanism by which acupuncture may promote healing in this condition remains largerly unknown. This lack of understanding constrains the development of improved treatments and is an obstacle to the integration of acupuncture into the mainstream management of LBP. Moreover, the mechanism of LBP itself is poorly understood, further impairing efforts to investigate treatment mechanisms. This study will provide new, objective measurements of phenomena fundamental to both acupuncture and LBP. Demonstrating that acupuncture needling responses are abnormal in LBP, and understanding why these responses are abnormal will bring us one step closer to understanding 1) why LBP occurs and 2) how acupuncture can promote healing in this common and disabling condition.

描述（由申请人提供）：本提案的目的是检验总体假设，即患有慢性或复发性腰痛 (LBP) 的受试者对针灸针刺有异常的软组织反应，并且这种改变的反应与异常的肌周神经相关。结缔组织结构和生物力学。我们还将测试腰痛中针刺反应的改变是否是普遍的，或者是像传统针灸理论所预测的那样局限于特定位置。 80 名 LBP 和 80 名无 LBP 受试者将使用计算机机器人针灸和超声弹性成像进行一次测试。将在经络与非经络以及背部和腿部的穴位与非穴位的腰痛与无腰痛中比较针扭矩、力和组织位移模式（目标 1）。我们还将通过测量肌周结缔组织厚度、超声信噪比、结构连续性和生物力学参数（刚度和阻尼）来评估腰部软组织结构和生物力学特征（目标 2）。实现本研究的目标将 1) 增进我们对针灸机制的理解 2) 为研究结合结缔组织和神经可塑性的新腰痛动态病理生理学模型提供第一步，以及 3) 提供结缔组织结构和生物力学的客观结果测量，可用于未来针对腰痛的针灸和其他疗法的临床试验。相关性：尽管针灸广泛用于治疗腰痛 (LBP)，但针灸促进腰痛愈合的机制仍不清楚。这种缺乏了解限制了改进治疗方法的发展，也是针灸融入腰痛主流治疗的障碍。此外，人们对腰痛本身的机制知之甚少，这进一步削弱了研究治疗机制的努力。这项研究将为针灸和腰痛的基本现象提供新的、客观的测量。证明腰痛的针刺反应是异常的，并了解这些反应为何异常，将使我们更进一步了解 1) 为什么会发生腰痛，以及 2) 针灸如何促进这种常见且致残的病症的愈合。