The Rutgers Mapping Resources

罗格斯大学测绘资源

• 批准号: 7234626
• 负责人: TARA C. MATISE
• 金额: $ 10.78万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-10 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7234626
• 关键词: Animals; Base Sequence; Canis familiaris; Chromosome Mapping; Collection; Commit; Communities; Computer software; Computers; Count; Custom; Data; Development; Documentation; Ensure; Facility Construction Funding Category; Genes; Genetic; Genetic Research; Genome; Genomics; Health; Hereditary Disease; Human; Human Genetics; Inherited; Instruction; International; Internet; Letters; Localized Disease; Mails; Maintenance; Maps; Meiotic Recombination; Methods; Mus; Numbers; Online Systems; Organism; Physical Map of the Human Genome; Plants; Play; Polymorphic Microsatellite Marker; Procedures; Protocols documentation; Publications; Radiation Hybrid Map; Radiation Hybrid Mapping; Rattus; Research Personnel; Resources; Role; Site; Update; base; computer program; design; evaluation/testing; genotyping technology; improved; interest; novel; physical mapping; programs; response; Animals; Base Sequence; Canis familiaris; Chromosome Mapping; Collection; Commit; Communities; Computer software; Computers; Count; Custom; Data; Development; Documentation; Ensure; Facility Construction Funding Category; Genes; Genetic; Genetic Research; Genome; Genomics; Health; Hereditary Disease; Human; Human Genetics; Inherited; Instruction; International; Internet; Letters; Localized Disease; Mails; Maintenance; Maps; Meiotic Recombination; Methods; Mus; Numbers; Online Systems; Organism; Physical Map of the Human Genome; Plants; Play; Polymorphic Microsatellite Marker; Procedures; Protocols documentation; Publications; Radiation Hybrid Map; Radiation Hybrid Mapping; Rattus; Research Personnel; Resources; Role; Site; Update; base; computer program; design; evaluation/testing; genotyping technology; improved; interest; novel; physical mapping; programs; response

DESCRIPTION (provided by applicant): Genetic linkage maps continue to play a critical role for gene mapping studies in humans and other organisms. Radiation hybrid maps are also playing an important role in the genome projects of several animal species. The Rutgers Mapping Resources are a unique collection of software programs, maps, and web applications designed to facilitate the construction and dissemination of several types of genomic maps. The Rutgers Mapping Resources include the MultiMap/CRIMAP program, the Rutgers Gombined Linkage- Physical Map, and the MAP-O-MAT web-based mapping server. MultiMap automates and facilitates the construction of linkage and radiation hybrid maps. The Rutgers Combined Linkage-Physical Map is the most comprehensive linkage map available to date, and is novel in that it incorporates both meiotic recombination map data as well as sequence-based positional information. MAP-O-MAT is a web-based server with data and applications for automated linkage mapping of human polymorphic markers, and is our mechanism for dissemination of the Rutgers Maps. These resources have served, and continue to serve, an important role in the international genetics research community, for studies in humans as well as other species. The basis for this claim comes from the numerous citations of our resource publications, many strong letters of support from current users, tallies of hits to our WWW/FTP sites, and the frequent and varying e-mail inquiries we receive. The Rutgers Mapping Resources have been used to help localize disease genes for many inherited genetic disorders with significant health impact. Under this proposal we will continue to develop these important resources in order to enhance and maintain their utility for investigators studying humans and other species. In particular, we propose to implement an interpolation method for placing physically-mapped markers onto our combined linkage-physical map, a feature which has growing importance as high-throughput genotyping technologies continue to advance. We will apply our combined-mapping procedure to data from the genome projects of non-human species such as mouse, rat, dog, and others. We will improve our MAP-O-MAT web server and develop a stand-alone shareable version. We will enhance our documentation, online help, and create useful new tutorials for all of our resources. We will also improve our resource integration and continue to maintain these resources while providing excellent user support. We remain fully committed to keeping all of our software and resources freely available. Our proposal is submitted under PAR-05-057 "Continued development and maintenance of software," which aims to "support the continued development, maintenance, testing and evaluation of existing software."

描述（由申请人提供）：遗传连锁图继续在人类和其他生物中的基因映射研究中起关键作用。辐射混合图在几种动物物种的基因组项目中也起着重要作用。 Rutgers映射资源是软件程序，地图和Web应用程序的独特集合，旨在促进几种类型的基因组图的构建和传播。 RUTGERS映射资源包括Multimap/Crimap程序，Rutgers GOMBIND链接物理图和基于Map-O-Mat Web的映射服务器。 Multimap自动化并促进链接和辐射混合图的构建。罗格人组合的链接 - 物理图是迄今为止可用的最全面的链接图，并且是新颖的，因为它同时包含了减数分裂重组图数据以及基于序列的位置信息。 MAP-O-MAT是一家基于Web的服务器，其数据和应用程序用于人类多态性标记的自动链接映射，并且是我们传播Rutgers Maps的机制。这些资源在国际遗传学研究界中为人类和其他物种的研究服务并继续发挥了重要作用。该主张的基础来自我们资源出版物的众多引用，现有用户的许多强烈支持信，对我们的www/ftp网站的命中率以及我们收到的频繁且不同的电子邮件查询。 Rutgers映射资源已用于帮助定位许多具有重大健康影响的遗传遗传疾病的疾病基因。根据这项提议，我们将继续开发这些重要资源，以增强和维护研究人和其他物种的研究人员的效用。特别是，我们建议实施一种插值方法，以将物理映射的标记放置在我们组合的链接 - 物理图上，该功能随着高通量基因分型技术的继续发展而越来越重要。我们将将合并映射程序应用于来自小鼠，大鼠，狗等非人类物种的基因组项目的数据。我们将改善MAP-O-MAT Web服务器并开发独立共享版本。我们将增强文档，在线帮助，并为我们所有资源创建有用的新教程。我们还将改善我们的资源集成，并继续维护这些资源，同时提供出色的用户支持。我们仍然完全致力于免费提供所有软件和资源。我们的建议根据“持续开发和维护软件的持续开发和维护”，旨在“支持持续开发，维护，测试和评估现有软件”。