TRAINING IN GENETICS OF COMPLEX BEHAVIORS IN AGING

衰老过程中复杂行为的遗传学培训

• 批准号: 7226695
• 负责人: GEORGE P VOGLER
• 金额: $ 12.92万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7226695
• 关键词: Aging; Behavior; Complex; Genetic; Training

DESCRIPTION (provided by applicant): Competitive renewal is sought for a training program trains interdisciplinary scholars who can advance and apply the concepts and methods of quantitative and molecular genetics to problems of health-related and functional behaviors in late adulthood and old age. The unique strength of the program lies in its integration of disparate research perspectives and strategies needed to investigate the complexities of variability in behavioral traits in the elderly. These perspectives include quantitative and molecular genetics, reductionist and integrationist approaches to modeling complex traits, measurements of genotypic and environmental influences, biology and behavior, demographic and biological influences of stress, human and animal research, and experimental and epidemiological approaches. Predoctoral trainees will pursue doctoral degrees in Biobehavioral Health, Human Development and Family Studies, Sociology, or Genetics. Students will be engaged actively in genetic research throughout their training, beginning with rotation through diverse laboratories including molecular genetics, quantitative modeling, a barrier facility or conventional mouse lab, demography research lab, or gene expression lab in addition to intensive continuous research in a specific area of emphasis. Students will enroll in a course on behavior genetics of age-related phenotypes in which a complete research project will be undertaken. They will participate in a weekly seminar on ethics or current issues throughout their training. Rich opportunities are available for quantitative and molecular genetics of complex age-related traits in both human subjects and animal models. Facilities and resources include several twin and population-based studies of elderly individuals; large-scale mouse studies focusing on QTL analysis of age-related phenotypes; extensive computational facilities for quantitative genetic model development and model-fitting; molecular genetic and gene expression facilities; and epidemiologic investigations. Postdoctoral fellows will participate in aspects of the formal training that complement their specialty training in order to train them as interdisciplinary scientists who are capable of functioning as independent scientists in a collaborative, multidisciplinary field of genetics of complex traits in an aging context. They will participate in the continuous weekly seminar on ethics and current issues. The training faculty are committed to interdisciplinary research and training with an emphasis on genetics of age-related behaviors, and have both a long history of collaboration in research and training in this area and new collaborative opportunities. The training faculty have ideal complementary expertise in the areas necessary to fulfill the interdisciplinary goals of this training program.

描述（由申请人提供）：寻求竞争性更新的培训计划训练跨学科学者，他们可以促进并将定量和分子遗传学的概念和方法应用于成年和老年晚期与健康相关和功能行为的问题。该计划的独特优势在于它整合了研究老年人行为特征的复杂性所需的不同研究观点和策略。这些观点包括定量和分子遗传学，还原主义和整合主义的方法来建模复杂性状，基因型和环境影响的测量，生物学和行为，生物学和行为，压力，人类和动物研究，实验性和实验性和流行病学方法的人口统计学和生物学影响。 托管前学员将攻读生物行为健康，人类发展和家庭研究，社会学或遗传学的博士学位。从整个培训中，学生将积极参与遗传研究，首先是通过各种实验室的旋转，包括分子遗传学，定量建模，障碍设施或常规小鼠实验室，人口统计研究实验室或基因表达实验室，除了在特定强调领域进行大量持续研究外。学生将参加与年龄相关表型的行为遗传学课程，其中将进行一个完整的研究项目。他们将在整个培训期间参加有关道德或当前问题的每周一次研讨会。丰富的机会可用于人类受试者和动物模型中复杂年龄相关性状的定量和分子遗传学。设施和资源包括对老年人的几项基于双胞胎和人群的研究；大规模的小鼠研究重点是与年龄相关表型的QTL分析；定量遗传模型开发和模型拟合的广泛计算设施；分子遗传和基因表达设施；和流行病学研究。 博士后研究员将参加正式培训的各个方面，以补充他们的专业培训，以便他们成为跨学科的科学家，他们能够在衰老环境中复杂性状的合作，多学科遗传学领域中充当独立科学家。他们将参加有关道德和当前问题的连续每周研讨会。培训学院致力于跨学科研究和培训，重点是与年龄有关的行为的遗传学，并且在该领域的研究和培训方面既有悠久的协作历史，又有新的合作机会。 培训学院在实现该培训计划的跨学科目标所需的领域具有理想的补充专业知识。