MicroPET/CT for Small Animal Imaging

用于小动物成像的 MicroPET/CT

基本信息

批准号：
7125729
负责人：
Henry F. VanBrocklin
金额：
$ 127.71万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-01 至 2009-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7125729
关键词：
Adoption Aging Algorithms Animal Cancer Model Animal Disease Models Animal Model Animals Applications Grants Area Arts Basic Science Beds Biodistribution Biomedical Research Brain Carbon Cardiac Cardiology Cardiovascular Diseases Cardiovascular system Chemistry Class Clinical Clinical Medicine Clinical Sciences Clinical Trials Commit Communities Compatible Comprehensive Cancer Center Cyclotrons Daily Data Data Set Databases Development Diagnosis Discipline Discipline of Nuclear Medicine Disease Disease Progression Dose Drug Delivery Systems Evaluation Faculty Feasibility Studies Fluorine Functional Imaging Funding Future Goals Grant Growth Housing Human Human Biology Human Resources Hybrids Image Image Analysis Imagery Imaging Device Imaging Techniques Individual Institution Investigation Knock-out Label Laboratories Laboratory Research Lead Life Malignant Neoplasms Maps Measurement Measures Medical Medical Imaging Medical Research Methods Modality Modeling Molecular Molecular Genetics Monitor Myocardial Infarction Neoplasm Metastasis Neurology Neurosciences Neurosciences Research Neurotransmitter Receptor Numbers Organism PET/CT scan Perfusion Pharmaceutical Preparations Photons Physics Positron-Emission Tomography Primates Procedures Process Productivity Quality of life Radioisotopes Radiolabeled Radiology Specialty Radionuclide Imaging Radiopharmaceuticals Range Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Resolution Resources Rodent Role San Francisco Scientist Sensory Receptors Site Software Tools Stem cells System Techniques Technology Thallium Therapeutic Time Toxic effect Tracer Transgenic Organisms Translational Research Translations United States National Institutes of Health Visual Work anticancer research attenuation base cardiovascular imaging cohort design drug development drug discovery human subject image visualization improved in vivo instrument instrumentation interest member microsystems molecular imaging nervous system disorder neurosurgery novel diagnostics novel therapeutics programs radiotracer reconstruction research and development response single photon emission computed tomography size technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane tissue regeneration tool tumor tumorigenesis uptake

项目摘要

DESCRIPTION (provided by applicant): Over the past decade, molecular imaging has emerged as the most important new direction in medical imaging research. This discipline is targeted at the use and development of new instrumentation, techniques, and probes for understanding the molecular and genetic basis of human biology and disease. With this proposal we seek to acquire a state-of-the-art Siemens (formerly Concorde Microsystems) hybrid microPET/microCAT QS scanner to support multiple projects that span the breadth of biomedical research and will greatly enhance molecular imaging research at UCSF. The microPET/CT will combine a high resolution PET with improved sensitivity and a high resolution CT to afford both functional and anatomical imaging without having to move the subject or transfer a bed between to independent scanners. UCSF, a world leader in biomedical research and medical imaging, has recently opened the Center for Molecular and Functional Imaging (CMFI). Significant resources have been committed to consolidate the Department of Radiology imaging research programs, site a cyclotron, provide the laboratory infrastructure and recruit key personnel to build a world class radiopharmaceutical development and imaging program. The microPET/CT is one of the key components that is critically needed to achieve the long term goals of the CMFI by providing an important molecular imaging tool for the UCSF research community. Seventeen research projects, largely supported by NIH funds, have been identified that will directly benefit from access to the microPET/CT. This systern will significantly enhance the molecular imaging research program by facilitating current research as well as enabling future NIH projects at UCSF and collaborating institutions within the greater San Francisco Bay Area.

描述（由申请人提供）：在过去的十年中，分子成像已成为医学成像研究中最重要的新方向。该学科的目的是使用和开发新的仪器，技术和探针，以理解人类生物学和疾病的分子和遗传基础。通过这项建议，我们试图获取最先进的西门子（以前是协和的微型系统）混合微型网/微型QS QS扫描仪，以支持跨越生物医学研究广度的多个项目，并将大大增强UCSF的分子成像研究。 MicroPET/CT将将高分辨率PET与提高灵敏度和高分辨率CT相结合，以提供功能性和解剖成像，而无需将受试者移动或将床转移到独立的扫描仪之间。 UCSF是生物医学研究和医学成像的全球领导者，最近开设了分子和功能成像中心（CMFI）。大量资源已致力于整合放射学成像研究计划，网站A Cyclotron，提供实验室基础设施，并招募关键人员，以建立世界一流的放射性药物开发和成像计划。 MicroPET/CT是通过为UCSF研究社区提供重要的分子成像工具来实现CMFI的长期目标所需的关键组件之一。已经确定了将直接受益于对MicroPET/CT的访问，这将在很大程度上受益于NIH基金。该系统将通过促进当前的研究以及在更大的旧金山湾地区的UCSF和合作机构中实现未来的NIH项目，从而显着增强分子成像研究计划。