Studies of Amino Acid Neurotransmitter Contributions to Depression

氨基酸神经递质对抑郁症影响的研究

• 批准号: 7265231
• 负责人: GERARD SANACORA
• 金额: $ 12.68万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7265231
• 关键词: Acetates; Address; Affect; Alleles; Amino Acid Neurotransmitters; Amino Acids; Area; Award; Brain; Brain region; Clinical; Clinical Trials; Data; Development; Development Plans; Diagnosis; Diagnostic Procedure; Disease; Drug Delivery Systems; Educational Curriculum; Environment; Extramural Activities; Functional disorder; Funding; Genes; Genotype; Glucose; Glutamates; Glutamine; Goals; In Vitro; Individual; Infusion procedures; Investigation; Label; Laboratories; Lead; Magnetic Resonance; Magnetic Resonance Spectroscopy; Measures; Mental Depression; Mentors; Mentorship; Methodology; Methods; Modality; Molecular Neurobiology; Mood Disorders; National Institute of Mental Health; Neurobiology; Neuroglia; Occipital lobe; Pathology; Peer Review; Phase; Prefrontal Cortex; Productivity; Psychiatry; Publications; Rate; Research; Research Personnel; Role; Sampling; Single Nucleotide Polymorphism; System; Testing; Time; Training; Translational Research; Work; base; career; clinically relevant; clinically significant; experience; gamma-Aminobutyric Acid; improved; neurotransmission; novel diagnostics; skills; symposium; tool

DESCRIPTION (provided by applicant): This KO2 application seeks support that is essential for Dr. Sanacora's continued career development as a newly-independent clinical researcher. Funded by a NIMH K08 mentored career award (K08-MH-01715) Dr. Sanacora has attained considerable expertise in the use of magnetic resonance spectroscopy as a tool to investigate the role of amino acid neurotransmitter systems in the pathophysiology and treatment of mood disorders over the past 5 years. Thanks to the mentorship Dr. Sanacora received and the excellent environment provided to him through the Magnetic Resonance Center and the Department of Psychiatry at Yale he demonstrated considerable research productivity during this time as evidenced by his peer-reviewed publications and a recently-awarded RO1 (MH071676-01, G. Sanacora, P.I.). However, this K08 expired 6/31/04. This KO2 award is vital for sustaining Dr. Sanacora's current full-time research focus and for assuring his successful matriculation into a fully independent investigator. Justification for the award is provided by a comprehensive 5-year Career Development Plan that builds on his current expertise in the study of amino acid neurotransmitter contributions to mood disorders and the MRS methodologies used to investigate this area. Specifically, his goals are to acquire specialized skills in several additional areas that will make it possible for him to extend this work into areas of more direct scientific and clinical significance: 1) 13C-glucose MRS methods to measure rates of synthesis and cycling, 2) 13C-acetate studies to probe glial cell involvement in mood disorder pathology, 3) clinical trial experience to allow him to address the potential clinical usefulness of drugs targeting the amino acid neurotransmitter systems, and 4) basic molecular neurobiology related to amino acid neurotransmission that will enable him to continue to conduct relevant translational research in mood disorders. Intensive training is provided by an integrated curriculum of intramural coursework, extramural didactics, individualized preceptorships, interactive symposia, and research-related organizational meetings. Three representative studies are included to illustrate how the development of these skills will be used to advance the line of research that was initiated in his previous K08 award into the realms of pathophysiology and clinical practice. Thus, receiving this award would allow him the opportunity to improve the basic understanding of how the amino acid neurotransmitter systems and glial cell pathology contribute to the neurobiology of mood disorders. This work has direct clinical relevance since it is likely to lead to the development of novel diagnostic methods and treatment modalities for these disorders.

描述（由申请人提供）：此KO2申请寻求支持，这对于Sanacora博士作为新独立的临床研究人员的职业发展至关重要。由NIMH K08指导职业奖（K08-MH-01715）资助，Sanacora博士在使用磁共振光谱方面的使用方面具有相当大的专业知识，作为研究氨基酸神经递质系统在过去5年中的病理生理学和情绪失调治疗中的作用的工具。多亏了Sanacora博士获得的指导以及通过磁共振中心和耶鲁大学精神病学给他提供的极好环境，他在这段时间内证明了相当大的研究生产力，这一点有他的同行评审的出版物和最近授予的RO1（MH071676-01，G.Sanacora，P.I。）。但是，该K08于04年6月31日过期。该KO2奖对于维持Sanacora博士当前的全日制研究重点和确保其成功入学成为完全独立的研究人员至关重要。该奖项的理由是由一项全面的5年职业发展计划提供的，该计划基于他目前在研究情绪障碍的氨基酸神经递质贡献以及用于调查该领域的MRS方法方面的专业知识。具体而言，他的目标是在其他几个领域中获得专业技能，使他有可能将这项工作扩展到更直接的科学和临床意义的领域：1）1）13C-葡萄糖MRS MRS方法，以衡量合成和循环的速率，2）13c-乙酸研究，13C-乙酸研究，以探测临床病理学的临床范围，3）临床范围的临床范围，3）神经递质系统和4）与氨基酸神经传递有关的基本分子神经生物学，这将使他能够继续进行情绪障碍的相关转化研究。强化培训是由校园内课程，壁外教学，个性化录取，互动研讨会和与研究相关的组织会议的综合课程提供的。包括三项代表性研究，以说明如何使用这些技能的发展来推进其先前的K08奖奖中的研究领域的研究领域。因此，获得该奖项将使他有机会提高对氨基酸神经递质系统和神经胶质细胞病理学如何有助于情绪障碍神经生物学的基本了解。这项工作具有直接的临床相关性，因为它很可能导致这些疾病的新型诊断方法和治疗方式的发展。