Symposium: AHA Council on Basic Cardiovascular Sciences

研讨会：AHA 基础心血管科学委员会

• 批准号: 7254258
• 负责人: Michael David Schneider
• 金额: $ 1.5万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7254258
• 关键词: Acute; American Heart Association; Applications Grants; Behavior Therapy; Biology; Cardiovascular system; Cell Death; Cell Survival; Cells; Clinical Trials; Congestive Heart Failure; Devices; Evolution; Genes; Genome; Genomics; Goals; Heart Diseases; Heart failure; Human; Infarction; Link; Mission; Muscle Cells; Myocardial; Myocardial Ischemia; Myocardium; Numbers; Organ; Organism; Pharmaceutical Preparations; Purpose; Science; Scientist; Signal Transduction; Stem cells; Stress; Therapeutic; Tissues; Washington; adult stem cell; base; body system; functional genomics; genome sequencing; repaired; response; symposium

DESCRIPTION (provided by applicant): This multiple-year conference grant application (R13) seeks NHLBI support towards the establishment of an annual symposium sponsored by the American Heart Association's Council on Basic Cardiovascular Sciences, the world's leading organization of cardiovascular scientists. An evolution of more sporadic meetings held in Asilomar, Snowbird, and Seattle, this annual conference would further the scientific mission to understand normal and abnormal cardiovascular biology in seamless continuity from molecules, cells, and tissues to organs, organ systems, and organisms. In the current so-called "post-genomic" era, with the human genome sequencing complete, an intensely shared focus for much of our audience is linking genes to function in the cardiovascular system. By intent, we have superceded the alternating themes of "heart failure" and "infarction" used in prior years, with a much more integrated and broadly based scientific focus on functional genomics. For 2004, the unifying scientific theme of this conference will be the genome-wide response to stress in the cardiovascular system, a topic of especially current appeal. National strategic goals in heart disease cannot be met with off-the-shelf drugs, devices, and life-style modifications alone. Major therapeutic challenges include salvaging myocardium in acute ischemic heart disease and in congestive heart failure by inhibiting cardiac muscle cell death, by promoting cell survival signals, and by supplying or activating stem cells as a means to achieve myocardial repair. The potential utility of adult stem cells for these purpose exceeds even the most optimistic projections of a few years ago, and is reflected by the number of clinical trials already underway worldwide. The 1st Annual Symposium will be held July 14-18, 2004, in Stevenson, Washington, and was organized by Drs. Michael Schneider, Ivor Benjamin, Issei Komuro, and Stefanie Dimmeler. Dr. Schneider serves as the PI for this landmark conference grant proposal.

描述（由申请人提供）： 这份多年期会议拨款申请 (R13) 寻求 NHLBI 支持建立由美国心脏协会基础心血管科学委员会（世界领先的心血管科学家组织）主办的年度研讨会。这次年度会议是在阿西洛玛、雪鸟和西雅图举行的更多零星会议的演变，将进一步推进科学使命，即从分子、细胞和组织到器官、器官系统和生物体的无缝连续性了解正常和异常的心血管生物学。在当前所谓的“后基因组”时代，随着人类基因组测序的完成，我们许多观众共同关注的焦点是将基因与心血管系统功能联系起来。我们有意取代了前几年交替使用的“心力衰竭”和“梗死”主题，以更加综合和基础广泛的科学重点关注功能基因组学。 2004年，本次会议的统一科学主题将是全基因组对心血管系统压力的反应，这是当前特别有吸引力的话题。仅靠现成的药物、设备和生活方式的改变无法实现心脏病领域的国家战略目标。主要的治疗挑战包括通过抑制心肌细胞死亡、促进细胞存活信号以及通过供应或激活干细胞作为实现心肌修复的手段来挽救急性缺血性心脏病和充血性心力衰竭的心肌。成体干细胞用于这些目的的潜在效用甚至超过了几年前最乐观的预测，全球范围内正在进行的临床试验数量也反映了这一点。第一届年度研讨会将于 2004 年 7 月 14 日至 18 日在华盛顿州史蒂文森举行，由 Drs.迈克尔·施奈德、艾弗·本杰明、小室一诚和斯蒂芬妮·迪美勒。施耐德博士担任这项具有里程碑意义的会议资助提案的首席研究员。