2007 Microbial Population Biology

2007年微生物种群生物学

• 批准号: 7275630
• 负责人: Antony M. DEAN
• 金额: $ 0.25万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7275630
• 关键词: Antibiotic Resistance; Avian Influenza; Biology; Communicable Diseases; Computational Biology; Disease; Ecology; Epidemiology; Evolution; Funding; Genetic; HIV; Human; Influenza A Virus, H5N1 Subtype; Journals; Medical Microbiology; Modeling; Molecular Biology; Mutation; Paper; Participant; Physicians; Population; Population Biology; Population Genetics; Public Health; Range; Research; Research Personnel; Science; Scientist; Severe Acute Respiratory Syndrome; Systems Biology; Time; bacterial genetics; concept; falls; infectious disease evolution; innovation; microbial; pandemic influenza

Microbial population biology covers a diverse range of cutting edge issues in the microbial sciences and beyond. Firmly founded in evolutionary biology and with a strongly integrative approach, the GRC in Microbial Population Biology attracts researchers from evolutionary biology, ecology, computational biology, molecular biology, medical microbiology and epidemiology, bacterial genetics, population genetics, and more recently, systems biology. Research at the cutting edge of this rapidly growing field is consistently innovative (high impact papers in the top journals is the norm). This application seeks funding to support a special session on the evolution of infectious disease at the 2007 meeting of the Microbial Population Biology GRC. The emergence of new kinds of infectious disease (including antibiotic resistance) is a reality. Recent years have seen the emergence of HIV, SARS and the world remains acutely aware of the possibility of a new influenza pandemic. While the study of diseases typically falls within the domain of clinicians and microbiologists, the emergence of new infectious disease is primarily a problem in evolution and ecology. Molecular biology might tell us how many mutations are needed to switch from H5N1 (bird flu) to a form that is transmissible through human populations, but it is evolutionary biology that asks about the origin of these mutations, the order in which they need to occur and the likelihood of their occurrence: from this it becomes possible to build models and make predictions. Real progress in understanding the emergence of infectious disease and antibiotic resistance (including its control) requires that physicians talk with evolutionary biologists; that theorists talk with experimentalists. We propose to bring together a diverse spectrum of scientists in order to focus on cutting edge issues. The ensuing exchange of ideas ? particularly when fuelled by open debate among the full spectrum of meeting participants ? will provoke the emergence of new concepts and approaches for the study of the emergence of infectious disease that will ultimately make a difference to what is arguably the most significant public health issue of our time.

微生物种群生物学涵盖了各种各样的尖端问题 微生物科学及以后。牢固地建立在进化生物学中 并采用强烈的整合方法，在微生物种群中的GRC 生物学吸引了进化生物学，生态学，计算的研究人员 生物学，分子生物学，医学微生物学和流行病学，细菌 遗传学，人群遗传学以及最近的系统生物学。研究 在这个快速增长的领域的最前沿，始终是创新的（高 最高期刊的影响论文是常态。该申请寻求资金 支持有关2007年传染病进化的特别会议 微生物种群生物学的会议GRC。 新型传染病的出现（包括抗生素 抵抗）是现实。近年来已经看到了艾滋病毒的出现 而且世界仍然敏锐地意识到新流感的可能性 大流行。疾病的研究通常属于 临床医生和微生物学家，新传染病的出现是 主要是进化和生态学的问题。分子生物学可能会告诉我们 从H5N1（鸟流感）切换到形式需要多少个突变 通过人类种群可以传播，但是进化生物学是 询问这些突变的起源，他们需要的顺序 发生和发生的可能性：由此有可能 建立模型并做出预测。 理解传染病的出现的真正进步 和抗生素耐药性（包括其控制）要求医生谈话 与进化生物学家；理论家与实验者交谈。我们 提议将各种科学家汇集在一起​​，以专注于 尖端问题。随之而来的想法交流？特别是什么时候 在与参与者的全面辩论中进行公开辩论的推动？将要 引发新概念和方法的出现 传染病的出现，最终将改变什么 可以说是我们这个时代最重要的公共卫生问题。