2007 Epigenetics Gordon Research Conference

2007年表观遗传学戈登研究会议

• 批准号: 7319834
• 负责人: STEVEN E JACOBSEN
• 金额: $ 1.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-20 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7319834
• 关键词: Affect; Applied Research; Area; Biological Models; Biological Sciences; Biology; California; Chromosomes; DNA Methylation; Development; Disease; Epigenetic Process; Fostering; Future; Gene Expression; Gene Expression Regulation; Genome; Histones; Human Biology; International; Investments; Light; Los Angeles; Methodology; Modification; Oral; Organism; Participant; Plants; Post-Translational Protein Processing; Postdoctoral Fellow; Principal Investigator; Process; Range; Research; Research Personnel; Science; Scientist; Students; Time; Today; Tumor Suppressor Genes; Underrepresented Minority; Universities; Woman; X Inactivation; career; cost; frontier; posters; racial and ethnic; success; symposium

DESCRIPTION (provided by applicant): The Gordon Research Conference on Epigenetics is the premier venue for presenting new developments in one of the most exciting areas of the biological sciences today. Started in 1995 and now meeting for the seventh time, this conference has earned an international reputation for generating new research avenues as well as fostering progress in the more established areas of epigenetics. The conference has achieved this level of success by consistently providing a unique setting for bringing together a diverse group of scientists, and by cutting across boundaries of organism and methodology, to expand the frontiers of epigenetics research. In 2007 the conference will be co-chaired by mammalian biologist Anne Ferguson-Smith of University of Cambridge, and plant geneticist Steve Jacobsen at the University of California Los Angeles, both leaders in the field of epigenetics and long time participants of this conference. The study of epigenetics leads to an understanding of genome function. Epigenetic modifications such as methylation of the DNA and post-translational modification of core histones affect the organization and packaging of the chromosome, and hence gene expression. That these chromosomal marks are both dynamic and heritable leads to epigenetics being one of the most intriguing aspects of biology with a wide range of implications for development, disease, and natural variability. Epigenetic mechanisms are being elucidated through the study of a wide range of diverse organisms, and this conference prides itself on its inclusiveness of the full range of model systems. Given the importance of epigenetic gene regulation in mammalian processes such as X-chromosome inactivation, transposon control, and inappropriate silencing of tumor suppressor genes, as well as given the similarity of epigenetic gene regulation in different organisms, an understanding of epigenetic processes will shed light on a wide array of issues concerning human biology and disease. The conference has always placed a strong emphasis on the prominent participation of young investigators, as it is this group that so often defines the leading edge of research efforts. The organizers will strive to attract students and postdoctoral fellows to the field and promote the careers of students, postdoctoral fellows, and new principal investigators, by involving them in both the oral and poster presentations. They are also making a concerted effort to support women scientists and include participants of racial/ethnic backgrounds that are underrepresented in science. They will include underrepresented minorities during the selection of speakers and poster presenters from the submitted applications to the conference. This conference will be a worthwhile and cost-effective investment in the future of basic and applied research. Perhaps equally importantly, it will launch the careers of new scientists in this frontier area.

描述（由申请人提供）：戈登表观遗传学研究会议是展示当今生物科学最令人兴奋的领域之一的新进展的首要场所。 该会议于 1995 年召开，现已第七次召开，因开辟新的研究途径以及促进表观遗传学更成熟领域的进展而赢得了国际声誉。 此次会议取得了如此巨大的成功，因为它始终如一地提供了一个独特的环境，将不同的科学家群体聚集在一起，并跨越了有机体和方法论的界限，扩大了表观遗传学研究的前沿。 2007年的会议将由剑桥大学的哺乳动物生物学家Anne Ferguson-Smith和加州大学洛杉矶分校的植物遗传学家Steve Jacobsen共同主持，他们都是表观遗传学领域的领导者，也是该会议的长期参与者。 表观遗传学的研究有助于了解基因组功能。 DNA 甲基化和核心组蛋白翻译后修饰等表观遗传修饰会影响染色体的组织和包装，从而影响基因表达。 这些染色体标记既是动态的又是可遗传的，这使得表观遗传学成为生物学中最有趣的方面之一，对发育、疾病和自然变异具有广泛的影响。 通过对各种不同生物体的研究，表观遗传机制正在得到阐明，本次会议以其对所有模型系统的包容性而自豪。 鉴于表观遗传基因调控在哺乳动物过程中的重要性，例如X染色体失活、转座子控制和肿瘤抑制基因的不当沉默，以及不同生物体中表观遗传基因调控的相似性，对表观遗传过程的理解将有助于阐明关于人类生物学和疾病的广泛问题。 会议始终强调年轻研究人员的突出参与，因为正是这个群体经常定义研究工作的前沿。 组织者将努力吸引学生和博士后研究员进入该领域，并通过让学生、博士后研究员和新的首席研究员参与口头和海报展示来促进他们的职业生涯。 他们还共同努力支持女科学家，并包括在科学领域代表性不足的种族/民族背景的参与者。 在从提交给会议的申请中选择发言人和海报展示者时，他们将包括代表性不足的少数群体。 这次会议对于未来的基础和应用研究来说将是一次值得且具有成本效益的投资。 也许同样重要的是，它将开启这一前沿领域新科学家的职业生涯。