Modeling of Protein Interactions 2007

蛋白质相互作用建模 2007

• 批准号: 7407311
• 负责人: SANDOR VAJDA
• 金额: $ 0.5万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-10 至 2008-09-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7407311
• 关键词: Advisory Committees; Area; Attention; Behavior; Biochemistry; Biological; Biology; Biophysics; Cells; Collection; Complex; Cryoelectron Microscopy; Docking; Faculty; Female; Goals; Kansas; Mass Spectrum Analysis; Methodology; Methods; Minority; Minority-Serving Institution; Modeling; Numbers; Participant; Postdoctoral Fellow; Protein Structure Initiative; Proteins; Qualifying; Research Personnel; Role; Scientist; Sequence Analysis; Structure; Students; Techniques; Work; Working Women; base; concept; crosslink; day; improved; knowledge base; member; multidisciplinary; posters; protein protein interaction; protein structure; reconstruction; research study; symposium; tool; Advisory Committees; Area; Attention; Behavior; Biochemistry; Biological; Biology; Biophysics; Cells; Collection; Complex; Cryoelectron Microscopy; Docking; Faculty; Female; Goals; Kansas; Mass Spectrum Analysis; Methodology; Methods; Minority; Minority-Serving Institution; Modeling; Numbers; Participant; Postdoctoral Fellow; Protein Structure Initiative; Proteins; Qualifying; Research Personnel; Role; Scientist; Sequence Analysis; Structure; Students; Techniques; Work; Working Women; base; concept; crosslink; day; improved; knowledge base; member; multidisciplinary; posters; protein protein interaction; protein structure; reconstruction; research study; symposium; tool

DESCRIPTION (provided by applicant): Support is requested for the multidisciplinary conference Modeling of Protein Interactions 2007 (MPI2007) to be held September 30 - October 2, 2007 in Lawrence, Kansas. The meeting will involve a combination of biological, physical, and computational scientists, and will focus on challenges and available methodologies in the determination of protein complexes, including experimental studies, knowledge-based methods, sequence analysis, and structural approaches. The primary goal of MPI2007 will be to critically explore the availability of tools for improving the reliability of protein interaction information, focusing on broadly defined template-based modeling of protein-protein interactions. Since the analysis is based on the structures of proteins and incorporating additional information attempts to contribute to the understanding of their cellular roles, a large scale reconstruction of protein interactions will build on the results of the Protein Structure Initiative. Some of the fundamental questions we will discuss are as follows. Will protein docking evolve in a way similar to structure prediction? In other words, will knowledge-based methods provide the most useful information, and will be there enough protein-protein templates? Does a large-scale concerted effort to determine protein-protein templates, similar to PSI, make sense, at least in principle? Is the field mature enough to meet such a challenge? How can prediction tools be combined with a diverse set of experimental techniques (e.g., mass spectroscopy, cryoelectron microscopy, cross-linking, NMR, etc) to improve reliability? Experts from various areas of protein interactions were selected to serve on the Advisory Committee and to present at the conference. Further presentations will be selected by the Advisory Committee to cover all major methodologies of protein complex determination and modeling. A growing number of highly qualified women are working in the areas covered by the conference and the female speakers will be represented in each section. A poster session will be held on one of the conference days. The conference will be relatively small - approximately 100 participants. The organizers will pay special attention to attracting young investigators as speakers and poster presenters. Participation of students and postdoctoral fellows will be encouraged. Efforts will be made to diversify the participation by attracting minority scientists and graduate students by contacting faculty members working in the areas of Biophysics and Biochemistry in minority-serving institutions. The concept of the cell as a collection of multisubunit protein machines that determine its behavior in normal and diseased states is emerging as a cornerstone of modern biology. The planned Modeling of Protein Interactions 2007 (MPI2007) meeting will involve a combination of biological, physical, and computational scientists, and will focus on challenges and available methodologies in the determination of protein complexes, including experimental studies, knowledge-based methods, sequence analysis, and structural approaches.

描述（由申请人提供）：要求对2007年蛋白质相互作用（MPI2007）的多学科会议建模（2007年）于2007年9月30日至2007年10月2日在堪萨斯州劳伦斯举行。这次会议将涉及生物，物理和计算科学家的结合，并将重点关注蛋白质复合物的挑战和可用方法，包括实验研究，基于知识的方法，序列分析和结构方法。 MPI2007的主要目标是批判性地探索用于提高蛋白质相互作用信息可靠性的工具的可用性，重点是基于蛋白质 - 蛋白质相互作用的基于广泛定义的模板建模。由于该分析基于蛋白质的结构，并结合了其他信息来有助于理解其细胞角色，因此对蛋白质相互作用的大规模重建将基于蛋白质结构倡议的结果。 我们将讨论的一些基本问题如下。蛋白质对接会以类似于结构预测的方式发展吗？换句话说，基于知识的方法会提供最有用的信息，并且会有足够的蛋白质 - 蛋白质模板吗？至少在原则上，确定与PSI相似的蛋白质 - 蛋白质模板的大规模协同努力是否有意义？该领域足够成熟，可以满足这样的挑战吗？如何将预测工具与多种实验技术（例如质谱，冷冻电子显微镜，交联，NMR等）结合使用以提高可靠性？ 选择了来自各个蛋白质相互作用领域的专家来担任咨询委员会并参加会议。咨询委员会将选择进一步的演讲，以涵盖蛋白质复杂确定和建模的所有主要方法。越来越多的高素质妇女在会议涵盖的领域工作，每个部分将代表女性演讲者。在会议的时间之一将举行海报会议。会议将相对较小 - 大约100名参与者。组织者将特别注意吸引年轻的调查员作为演讲者和海报演示者。将鼓励学生和博士后研究员的参与。通过与在少数派服务机构的生物物理学和生物化学领域的教职员工联系，通过吸引少数群体科学家和研究生来使参与度多样化。该细胞作为确定其在正常和患病状态的行为的多亚基蛋白机器的集合的概念正在成为现代生物学的基石。蛋白质相互作用2007（MPI2007）会议的计划建模将涉及生物，物理和计算科学家的结合，并将重点介绍确定蛋白质复合物的挑战和可用方法，包括实验研究，基于知识的方法，序列分析和结构方法。