Large Simple Neuroprotective Trials in Parkinson's Disease

帕金森病的大型简单神经保护试验

• 批准号: 7157549
• 负责人: Caroline M. Tanner
• 金额: $ 9.37万
• 依托单位: PARKINSON'S INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7157549
• 关键词: 1-Methyl-4-phenylpyridinium; Age; Agreement; Biochemical; Cells; Characteristics; Clinical; Clinical Trials; Complex; Conduct Clinical Trials; Confidentiality; Controlled Clinical Trials; Disease Progression; Dopamine; Educational Activities; Elderly; Enhancers; Enrollment; Environment; Evolution; Funding; Ganglioside GM1; Glycogen Branching Enzyme; Goals; Hepatocyte; Human; Institutes; Investigation; Laboratory Animals; Mediating; Metabolic Biotransformation; Mitochondria; Modeling; Multicenter Trials; Mus; NADH dehydrogenase (ubiquinone); Nerve Degeneration; Neurodegenerative Disorders; Neuroprotective Agents; Neurotoxins; North America; Numbers; Pargyline; Parkinson Disease; Participant; Patients; Physicians; Population; Primates; Public Health; Publishing; Qualifying; Range; Research; Safety; Series; Staging; Structure; Substantia nigra structure; Support Groups; Testing; Time; Toxic effect; alpha Tocopherol; base; data integrity; deprenyl; design; dopaminergic neuron; drug testing; experience; insight; interest; neuroprotection; pars compacta; prevent; promoter; prospective; social; tissue culture; volunteer

DESCRIPTION (provided by applicant): The goal of this clinical center application is to describe the qualifications of the Parkinson's Institute as a participant in the large simple trial of neuroprotective therapy for Parkinson's disease as proposed in RFA NS-02-010. The Parkinson's Institute has a supportive research environment, extensive clinical trials experience and highly qualified staff, together with experience in the recruitment of clinical trials volunteers and an excellent relationship with support groups. Institute staff have more than 80 years of combined experience in clinical trials, primarily investigating therapies for Parkinson's disease. The Parkinson's Institute has considerable experience in recruitment from a large patient population, through physician contacts, through support groups contacts, media and educational activities. The Parkinson's Institute has an excellent track record regarding the administrative aspects of clinical trials conduct, including subject safety, confidentiality of information, timely enrollment of subjects, timely completion of study materials and data integrity. These characteristics make the Parkinson's Institute an ideal participant in the proposed trial.

描述（由申请人提供）：该临床中心申请的目的是描述帕金森病研究所作为 RFA NS-02-010 中提出的帕金森病神经保护治疗大型简单试验参与者的资格。帕金森研究所拥有支持性的研究环境、丰富的临床试验经验和高素质的工作人员，以及招募临床试验志愿者的经验以及与支持团体的良好关系。研究所工作人员在临床试验方面拥有 80 多年的综合经验，主要研究帕金森病的治疗方法。帕金森病研究所在通过医生接触、支持团体接触、媒体和教育活动从大量患者群体中招募患者方面拥有丰富的经验。帕金森研究所在临床试验管理方面拥有良好的记录，包括受试者安全、信息保密、受试者及时入组、及时完成研究材料和数据完整性。这些特征使帕金森研究所成为拟议试验的理想参与者。