Adolescent Alcohol Intake Effects on Mesolimbic Dopamine

青少年酒精摄入对中脑边缘多巴胺的影响

• 批准号: 7111177
• 负责人: JAMIE E TOALSTON
• 金额: $ 2.86万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7111177
• 关键词: adolescence (12-20); alcoholic beverage consumption; behavioral /social science research tag; disease /disorder proneness /risk; dopamine; drug habituation; early experience; ethanol; laboratory rat; limbic system; mature animal; microdialysis; microinjections; neuroanatomy; neurotoxicology; nucleus accumbens; operant conditionings; predoctoral investigator; reinforcer; self medication; substance abuse related behavior

DESCRIPTION (provided by applicant): The long-range goal of this proposal is to examine the effects of adolescent-alcohol drinking experience on the brain reward system. The hypothesis of the present proposal is that neuroadaptations in the brain's reward systems occur during adolescent alcohol drinking, increasing behavioral and neurobiological sensitivity to alcohol in adulthood. Operant techniques will first be used to examine alcohol-seeking behaviors, determining differences in the amount of work subjects are willing to perform for reward. Then, intracranial self-administration (ICSA) and microinjection-microdialysis techniques will be used illuminate effects on reward within the mesolimbic dopamine system. Adolescent male and female rats from the selectively bred alcohol-preferring P line will be used because they readily demonstrate an operant sensitivity to the rewarding effects of alcohol after peri-adolescent exposure. The overall purpose of this research is to improve the current understanding of the neurobiological mechanisms underlying the increased sensitivity to alcohol present after adolescent alcohol drinking experience, which may contribute to risk for alcoholism.

描述（由申请人提供）：该提案的长期目标是研究青少年饮酒经历对大脑奖励系统的影响。本提议的假设是，大脑奖励系统的神经适应发生在青少年饮酒期间，从而增加了成年期对酒精的行为和神经生物学敏感性。操作技术将首先用于检查寻求酒精的行为，确定受试者愿意为奖励而执行的工作量的差异。然后，颅内自我给药（ICSA）和显微注射微透析技术将用于阐明中脑边缘多巴胺系统内奖赏的影响。将使用来自选择性繁殖的酒精偏好 P 系的青春期雄性和雌性大鼠，因为它们在青春期暴露后很容易表现出对酒精奖励作用的操作敏感性。这项研究的总体目的是提高目前对青少年饮酒经历后对酒精敏感性增加的神经生物学机制的理解，这可能会导致酗酒的风险。