Preclinical Vector Core

临床前载体核心

• 批准号: 7144460
• 负责人: ANDREA GAMBOTTO
• 金额: $ 71.21万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-29 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7144460
• 关键词: Adenoviridae; Herpesviridae; adeno associated virus group; biomedical facility; biotechnology; cell line; gene delivery system; gene expression; plasmids; transfection /expression vector

The Vector Core has been and will function within the framework of the National Heart, Lung, and Blood Institute as a dynamic resource that can provide state-of-the-art viral vector technology as well as develop novel vectors. The Vector Core is able to generate retroviral, adenoviral, adeno-associated virus and herpesvirus vectors for gene delivery. The Vector Core will continue to develop and provide stocks of retroviral, adenoviral, adeno-associated and herpesviral vectors for gene delivery. The role of the Vector Core will remain to be to construct and provide vectors expressing the appropriate genes for investigators within the National Heart, Lung, and Blood Institute. In addition, the core will provide cell lines, viruses, packaging lines, plasmids, and protocols as needed to NHLBI funded investigators. The Core also will maintain to work with the NHLBI investigators to optimize viral and non-viral gene delivery and gene expression and provide technical assistance and training in the use of viral and non-viral vectors for gene transfer as needed.

载体核心已经并将在国家心肺血液研究所的框架内发挥作用，作为一种动态资源，可以提供最先进的病毒载体技术以及开发新型载体。 Vector Core 能够生成用于基因传递的逆转录病毒、腺病毒、腺相关病毒和疱疹病毒载体。载体核心将继续开发和提供用于基因传递的逆转录病毒、腺病毒、腺相关病毒和疱疹病毒载体库存。载体核心的作用仍然是为国家心肺血液研究所的研究人员构建和提供表达适当基因的载体。此外，该核心还将根据 NHLBI 资助的研究人员的需要提供细胞系、病毒、包装线、质粒和方案。该核心还将继续与 NHLBI 研究人员合作，优化病毒和非病毒基因传递和基因表达，并根据需要提供使用病毒和非病毒载体进行基因转移的技术援助和培训。