High-Performance Transparent Optical Ceramic Scintillators through Nanotechnology

采用纳米技术的高性能透明光学陶瓷闪烁体

基本信息

批准号：
7327556
负责人：
ALEXANDER LEMPICKI
金额：
$ 14.45万
依托单位：
RADIATION MONITORING DEVICES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-08-01 至 2008-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7327556
关键词：
Aluminum Oxide Alzheimer&apos s Disease Area Biological Biological Process Body Image Carbon Isotopes Ceramics Cereals Characteristics Collaborations Condition Coupled Craniocerebral Trauma Cytoplasmic Granules Dependence Development Diagnosis Digital Radiography Dimensions Disease Dose Equipment Fluorine Functional Imaging Future Gamma Rays Goals Growth High temperature of physical object Image Imaging Techniques Investigation Joint Ventures LSO crystal Label Lead Life Light Lutetium Malignant Neoplasms Measures Medical Methods Mind Modification Monitor Nanotechnology Nature Nitrogen Nuclear Optics Output Oxygen Particle Size Performance Phase Photons Play Porosity Positron Positron-Emission Tomography Powder dose form Procedures Process Property Range Rate Reporting Reproducibility Research Residual state Resolution Role Source Specimen Staging Stroke Structure Symptoms System Techniques Technology Temperature Time Tracer Tube Visible Radiation Work clinical Diagnosis cost cost effective design desire detector experience gadolinium sulfoxylate improved in vivo instrument instrumentation interest mathematical model nanoparticulate nanopowder nanoscale novel strategies photomultiplier prevent research study response size

项目摘要

DESCRIPTION (provided by applicant): LSO is generally recognized as the ideal scintillator for PET. It has high stopping power for 511 keV gamma rays, high light yield of over 20000 photons/MeV, and rapid decay of 32 ns. It achieves high coincidence timing resolution and energy resolution. But single crystals of LSO are difficult and expensive to grow, reproducibility is poor, and the material is simply not available for general commercial use. To overcome these drawbacks, we have in our previous work developed a translucent LSO optical ceramic, which displays scintillation performance comparable to that of the single crystal, yet is easier to fabricate and could fill the availability gap at lower cost. But because LSO is optically anisotropic, it cannot be made fully transparent by conventional ceramic technology. Recently, however, a new process has been developed through nanotechnology that is capable of achieving virtually full transparency in ceramics of even optically anisotropic materials. The technique involves the consolidation of nanopowders under conditions that limit the ultimate grain sizes to below the wavelengths of visible light, thereby preventing virtually all scattering and rendering the material fully transparent. The procedure has been completely confirmed in experiments on polycrystalline alumina, which is similarly anisotropic, and is being developed for optical window applications. It is the aim of this proposal to combine the two already developed technologies so as to produce LSO in the form of a fully transparent optical ceramic, which displays scintillation performance comparable to that of a single crystal. In Phase I we will confirm that the process that has already been established for alumina is adaptable to LSO as well. We will establish techniques to fabricate the necessary nanoparticulate powders and to define the consolidation conditions under which the desired material properties can be achieved.

描述（由申请人提供）：LSO通常被认为是PET的理想闪光灯。它具有511 KEV伽玛射线的高停止功率，超过20000个光子/MEV的高光产量以及32 ns的快速衰减。它实现了高巧合的时序分辨率和能量分辨率。但是LSO的单晶很难生长，可重复性较差，而且该材料根本不可用于一般商业用途。为了克服这些缺点，我们在以前的工作中开发了一种半透明的LSO光学陶瓷，它显示出与单晶相当的闪烁性能，但易于制造，并且可以以较低的成本填补可用性空白。但是，由于LSO在光学上是各向异性的，因此传统陶瓷技术不能完全透明。然而，最近，通过纳米技术开发了一个新的过程，纳米技术能够在甚至光学各向异性材料的陶瓷上几乎完全透明。该技术涉及纳米植物在限制最终晶粒大小至可见光波长以下的条件下的巩固，从而防止所有散射和使材料完全透明。该过程已在多晶氧化铝上的实验中得到了完全确认，该氧化铝类似地是各向异性的，并且正在用于光学窗口应用。该提案的目的是将两种已经开发的技术结合起来，以便以完全透明的光学陶瓷形式产生LSO，该陶瓷表现出与单晶相当的闪烁性能。在第一阶段，我们将确认已经为氧化铝建立的过程也适用于LSO。我们将建立技术来制造必要的纳米颗粒粉末，并定义可以在这些粉末中实现所需材料特性的合并条件。