Domoic Acid Neurotoxicity in Native Americans

软骨藻酸对美洲原住民的神经毒性

基本信息

批准号：
7285196
负责人：
LYNN M GRATTAN
金额：
$ 111.57万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-20 至 2009-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7285196
关键词：
Adult Affect Age Alcohols Animal Model Animals Beds Canada Carbohydrates Cessation of life Child Child Development Chronic Clams Classification Cognition Cognitive Cohort Studies Communities Complex Consumption Data Detection Development Dietary intake Disease Outbreaks Doctor of Philosophy Drug usage Eating Education Elderly Exposure to Fatty acid glycerol esters Fisheries Fishes Food Food Safety Goals Harvest Health Health Status Human Impaired cognition Incidence Indian reservation Individual Industry Infant Intake Integration Host Factors Intervention Laboratories Left Life Life Style Marine Toxins Measurement Measures Medical Medical Education Memory Memory Disorders Monitor Morbidity - disease rate Mussels Native Americans Nature Pacific Northwest Participant Perinatal Exposure Persons Pharmaceutical Preparations Poisoning Population Predisposition Prevalence Preventive Prince Edward Island Proteins Public Health Purpose Range Regulation Research Design Risk Risk Factors Safety Sampling Scientist Sea Lions Shellfish Source Standards of Weights and Measures Survivors Symptoms Time Tobacco Toxic effect Tribes United States United States Food and Drug Administration Vitamins Work age group base design domoic acid gastrointestinal medically underserved member neurobehavioral neuropsychological neurotoxicity prevent sound tribal member

项目摘要

DESCRIPTION (provided by applicant): Domoic Acid (DA) is a naturally occuring marine toxin that is responsible for Amnestic Shellfish Poisoning (ASP), or even death in humans who consume tainted shellfish. Within the past decade, rising levels of DA on the US west coast has been responsible for outbreaks of toxicity affecting fish, shellfish, shorebirds and sealions. The highest levels of DA ever recorded in the United States (exceeding established safety levels of 20 ppm by more than 280 ppm) were found in harvesting beaches of several subsistence level Native American Tribes within the past four years. The purpose of this five year longitudinal cohort study of 625 Native Americans is to determine the incidence and prevalence of domoic acid related illness in this at-risk group and to identify both exposure and host factors associated with the occurrence of illness, including the effects of repeated "low" level exposure. Participants will be randomly selected from four US and one Canadian Tribe and will represent five at-risk age groups: infants, young children, older children, adults and geriatric. They will have varying levels of exposure and will be studied annually with standard, age-appropriate neuropsychological measures of memory and cognition. Exposure will be uniformly determined through 1) bi-monthly shellfish sampling and standard detection measures for DA conducted by NOAA from June to October of each year and 2) standardized dietary and shellfish consumption intake measurement. The study design will also enable us to determine the percent of the population with one or more risk factors, examine threshold levels of exposure for five different age groups, re-examine current FDA established safety levels for different age groups, and study the impact of early exposure on child development. Our ultimate goal is to provide a rational basis for shellfish regulation and preventive education to disproportionately exposed and medically underserved Native American communities.

描述（由申请人提供）：Domoic Acid（DA）是一种自然发生的海洋毒素，该毒素导致氨基鱼中毒（ASP），甚至是食用污染贝类的人类中的死亡。在过去的十年中，美国西海岸的DA水平上升一直导致影响鱼类，贝类，shore鸟和密封的毒性爆发。在过去四年中，在美国几个生存水平的海滩上发现了有史以来记录的最高水平（超过20 ppm的确定安全水平超过280 ppm）。这项五年对625名美洲原住民的纵向队列研究的目的是确定该高风险群体中与二氧酸有关的疾病的发生率和患病率，并确定与疾病发生有关的暴露和宿主因素，包括重复“低”水平暴露的影响。参与者将被随机从美国四个和一个加拿大部落中选出，并将代表五个处于危险的年龄段：婴儿，幼儿，大孩子，成人和老年医生。他们的暴露水平将有所不同，每年将通过标准的，适合年龄的记忆和认知的神经心理学度量进行研究。接触将通过1）NOAA从每年的6月至10月进行的双月贝类采样和标准检测指标均匀确定，而2）标准化的饮食和贝类消耗摄入量测量。研究设计还将使我们能够确定一个或多个风险因素的人口百分比，检查五个不同年龄段的阈值暴露水平，重新检查当前的FDA为不同年龄段的人群建立了安全水平，并研究了早期暴露对儿童发育的影响。我们的最终目标是为贝类监管和预防性教育提供合理的基础，以使暴露不成比例的美国原住民社区不成比例。