MSM Multiscale Human Respiratory System Simulations to Study Health Effects

MSM 多尺度人体呼吸系统模拟研究健康影响

• 批准号: 7271122
• 负责人: Robert Francis Kunz
• 金额: $ 16.36万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-26 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7271122
• 关键词: Address; Aging; Architecture; Biological; Clinical Data; Communities; Computer software; Confocal Microscopy; Coupling; Data; Dependency; Deposition; Dimensions; Disease; Elements; Evaluation; Goals; Health; High Resolution Computed Tomography; Human; Image; Injury; Kidney; Liquid substance; Literature; Liver; Lung; Mechanics; Microscopic; Modeling; Morphology; Multimodal Imaging; Nuclear Reactors; Operative Surgical Procedures; Organ; Phase; Physics; Physiological; Plug-in; Public Health; Range; Research; Research Infrastructure; Research Personnel; Respiration; Respiratory System; Respiratory physiology; Safety; Science; Simulate; Standards of Weights and Measures; Structure; System; Technology; X-Ray Computed Tomography; base; improved; multidisciplinary; novel; open source; physical model; respiratory; simulation; uptake; virtual human

DESCRIPTION (provided by applicant): A multi-scale strategy is proposed to develop, couple, apply, and validate multimodality imaging and physics modeling of resolvable and sub-resolvable scales in human respiration. High-resolution computed tomography (HRCT) will be used to characterize the "macroscale" convective range of the lung. Microscopic computed tomography (.CT), and confocal microscopy (CLSM), will be used to characterize the "microscale" global and cellular architectures of the respiratory units. Multiphase computational fluid dynamics and quasi-one-dimensional functional modeling will be used to simulate the multi-component fluid mechanics at the macro- and micro-scales, respectively. Software infrastructure and two-phase fluid mechanics models will be developed to address the coupling between the physics at these two scales. Model predictions will be validated against experimental and clinical data from the literature. A novel and critical element of the proposed research is that the interfaces between functional biological scales will be developed using recent dimension-reducing coupling strategies developed in the nuclear reactor safety/simulation community, and multidisciplinary data-exchange standards developed in the aerospace sciences community. Coupling technologies will be developed between macro- and microscales, and between imaging and physical modeling; these will yield a system-level model that accommodates the critical two-way coupling between convective respiration physics and uptake, deposition, and disease-state morphology. Such an integrated approach will elucidate heretofore inaccessible physical understanding, dependencies, and treatment implications. The coupling software to be developed will be modular and open-source so other investigators can "plug-in" their models at the macro- and micro-scales, and/or evolve the system to other organs or human systems such as the liver or kidney. The ultimate public health goal of the research is improved understanding of respiratory function and disease, and evaluation/assessments of the effects of therapies, injury, surgical intervention, and aging on lung structure and function. The physics-based coupling between multiple scales is a critical step towards a complete integrated physiological model of the human respiratory system: a "virtual human lung."

描述（由申请人提供）：提出了一种多尺度策略，以开发，夫妇，应用和验证人类呼吸中可分辨和亚避免量表的多模式成像和物理建模。高分辨率计算机断层扫描（HRCT）将用于表征肺的“宏观”对流范围。显微镜计算机断层扫描（.CT）和共聚焦显微镜（CLSM）将用于表征呼吸单元的“显微镜”全局和细胞结构。多相计算流体动力学和准二维功能建模将分别模拟宏观和微尺度的多组分流体力学。将开发软件基础架构和两相流体力学模型，以解决这两个量表的物理之间的耦合。模型预测将根据文献的实验和临床数据进行验证。拟议的研究的一个新颖而关键的要素是，将使用在核反应堆安全/仿真社区中开发的最新减少维度的耦合策略以及在航空航天科学社区中开发的多学科数据交流标准。耦合技术将在宏观和显微镜之间以及成像和物理建模之间开发；这些将产生一个系统级模型，该模型适合对流呼吸物理学与摄取，沉积和疾病状态形态之间的关键双向耦合。这种综合方法将阐明迄今无法访问的物理理解，依赖性和治疗意义。要开发的耦合软件将是模块化的和开源的，因此其他研究人员可以在宏观和微型尺度上“插入”其模型，并/或将系统进化到其他器官或人类系统，例如肝脏或肾脏。该研究的最终公共卫生目标是对呼吸功能和疾病的理解有了改善，以及对疗法，损伤，手术干预以及对肺结构和功能衰老的影响的评估/评估。多个尺度之间的基于物理的耦合是迈向人类呼吸系统完整综合生理模型的关键步骤：“虚拟人类肺”。