Metal and Organochlorines Exposure: Impact on Adolescent Behavior and Cognition

金属和有机氯暴露：对青少年行为和认知的影响

• 批准号: 7285315
• 负责人: SUSAN A KORRICK
• 金额: $ 58.93万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-08 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7285315
• 关键词: 13 year old; Adolescence; Adolescent Behavior; Adolescent Development; Age; Air; Archives; Area; Arsenic; Attention; Behavior; Behavior Control; Behavior Disorders; Behavior assessment; Behavioral; Birth; Boston; California; Child; Childhood; Chlorinated Hydrocarbons; Cognition; Cognitive; Communities; Development; Disease; Elderly; Environmental Pollution; Environmental Risk Factor; Epidemiologic Studies; Exposure to; Food Contamination; Hair; Hazardous Waste Sites; Hexachlorobenzene; Hyperactive behavior; Impairment; Individual; Joints; Language; Lead; Learning; Learning Disorders; Life; Manganese; Measures; Memory; Metal exposure; Metals; Methylmercury Compounds; Modeling; Morbidity - disease rate; Names; Neurocognitive; Neurotoxins; Outcome; Physiological; Polychlorinated Biphenyls; Population; Population Study; Public Health; Range; Research Personnel; Risk; Risk Factors; Role; Short-Term Memory; Site; Soil; Source; Specimen; Staging; Structure of nail of toe; System; Testing; Time; Umbilical Cord Blood; Verbal Learning; Water; Work; age group; age related; blood lead; cohort; executive function; experience; insight; lead exposure; neurotoxic; organochlorine exposure; performance tests; postnatal; prenatal; prenatal exposure; prospective; research clinical testing; skill acquisition; skills

DESCRIPTION (provided by investigator): Children are exposed to a mix of potential neurotoxicants, including metals, via widespread contamination of food, air, soil and, in some settings, water. Exposure to neurotoxicants during early development can be particularly deleterious. Furthermore, the substantial developmental and physiologic changes of adolescence have been shown to be sensitive to early life exposures and experience. Therefore adolescence represents a critical time for manifestations of early life exposure effects but there are few environmental epidemiologic studies of this age group. The primary aims of this study are to assess the relation of early life exposure to neurotoxic metal mixtures, and their interactions, with early adolescent behavior and cognition. The metals to be studied are prenatal manganese (Mn), methylmercury (MeHg), arsenic (As), lead (Pb) and postnatal Pb exposure. We will assess the relation of early life exposure to these metals, individually and jointly, with (1) behavior and cognition, particularly impulsive or hyperactive behaviors, attention, language skill, executive function, memory and learning skills among 13-year-olds; and (2) prospective changes in behavior and cognition between ages 8 and 13 years. (3) In addition, we will assess the role of prenatal exposure to prevalent organochlorines - polychlorinated biphenyls (PCBs), dichlorodiphenyl dichloroethene (DDE), and hexachlorobenzene (HCB) -- as effect modifiers of metal-behavior/cognitive associations. The proposed study population is a well characterized cohort of 788 children born between 1993-1998, residing adjacent to a PCBand metal-contaminated site and with low-level to moderate metal exposures. Prenatal Pb and organochlorine exposure measures, and archived cord blood, maternal hair and toenail specimens were obtained at birth and the children had developmental assessments from birth through age 8 years. In this study, archived birth specimens will be analyzed for Mn, MeHg, and As and detailed cognitive/behavioral assessments will be performed at age13 years on 500 of the children. The relation of metal exposures with neurocognitive skills will be assessed individually and with interaction terms for each outcome. Then, the relation of individual and multiple exposure measures with potentially correlated outcomes will be evaluated in a single multiple outcomes model. The study's behavioral and cognitive assessments will measures skills directly related to the risk of childhood learning and behavioral disorders. These increasing common childhood disorders represent a growing source of childhood and, in many cases, later life morbidity and public health concern. The proposed study provides a unique opportunity (given extensive prospective exposure/developmental information and specimen archives already available) to gain insight into potentially remediable risk factors for common behavioral and learning disorders of childhood at a time, adolescence, when there may be increasingly evident functional and behavioral manifestations of early life neurotoxicant exposures.

描述（由调查员提供）：通过食品、空气、土壤以及某些环境下的水的广泛污染，儿童接触到多种潜在的神经毒物，包括金属。在早期发育过程中接触神经毒物可能特别有害。此外，青春期的实质性发育和生理变化已被证明对早期生活的暴露和经历很敏感。因此，青春期是生命早期暴露效应表现的关键时期，但对该年龄段的环境流行病学研究很少。本研究的主要目的是评估生命早期接触神经毒性金属混合物及其相互作用与青少年早期行为和认知的关系。要研究的金属包括产前锰 (Mn)、甲基汞 (MeHg)、砷 (As)、铅 (Pb) 和产后铅暴露。我们将单独和联合评估生命早期接触这些金属的关系：(1) 13岁儿童的行为和认知，特别是冲动或过度活跃的行为、注意力、语言技能、执行功能、记忆和学习技能； (2) 8 至 13 岁之间行为和认知的预期变化。 (3) 此外，我们将评估产前接触常见有机氯——多氯联苯 (PCB)、二氯二苯基二氯乙烯 (DDE) 和六氯苯 (HCB)——作为金属行为/认知关联的影响调节剂的作用。拟议的研究人群是一个由 1993 年至 1998 年出生的 788 名儿童组成的特征明确的队列，他们居住在 PCB 和金属污染地点附近，金属暴露水平为低至中度。我们在出生时采集了产前铅和有机氯暴露测量数据以及存档的脐带血、母亲头发和脚趾甲样本，并对儿童从出生到 8 岁进行了发育评估。在这项研究中，将对存档的出生样本进行锰、甲基汞和砷分析，并对 500 名 13 岁儿童进行详细的认知/行为评估。金属暴露与神经认知技能的关系将单独评估，并根据每个结果的交互项进行评估。然后，将在单个多结果模型中评估个体和多重暴露测量与潜在相关结果的关系。该研究的行为和认知评估将衡量与 儿童学习和行为障碍的风险。这些日益常见的儿童期疾病代表了儿童期以及在许多情况下晚年发病率和公共卫生问题的日益增长的根源。拟议的研究提供了一个独特的机会（考虑到广泛的前瞻性暴露/发育信息和已有的标本档案），以深入了解儿童时期、青春期常见行为和学习障碍的潜在可补救的风险因素，此时可能存在越来越明显的功能性障碍。以及生命早期神经毒物暴露的行为表现。