Hemodynamic Imaging for Brain Tumor Prognosis

血流动力学成像用于脑肿瘤的预后

• 批准号: 7110500
• 负责人: HANLI LIU
• 金额: $ 34.28万
• 依托单位: UNIVERSITY OF TEXAS ARLINGTON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7110500
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; brain imaging /visualization /scanning; brain neoplasms; charge coupled device camera; hemodynamics; hemoglobin; histology; hyperoxia; infrared spectrometry; laboratory rat; mathematical model; miniature biomedical equipment; model design /development; neoplasm /cancer blood supply; noninvasive diagnosis; oxygen consumption; portable biomedical equipment; prognosis; radiation therapy

DESCRIPTION (provided by applicant): It is crucial and advantageous if tumors under therapy can be functionally monitored and imaged at different treatment stages. A non-invasive, portable, cost-effective, in vivo imaging tool is much needed to choose, guide and follow cancer therapy. The overall objective of this phased proposal is to develop such a novel imaging modality by utilizing Near Infrared (NIR) tomography in combination with hemodynamic modeling to functionally obtain hemodynamic images of animal brain tumors, which are under radio-surgery with and without respiratory interventions. The tomographic images of changes in hemoglobin concentrations, blood flow, and oxygen consumption rate of the brain tumor caused by different radiation doses in radio-surgery along with hyperoxic interventions can be obtained non-invasively and chronically. Such hemodynamic images may provide prognostic information, for clinical radio-surgery practice, on inhomogeneous responses of the tumor to the therapy and intervention as well as on the effectiveness of the therapy. There are three specific aims in the R21 phase: (1) to design and implement an 8-source, 8- detector, NIR spectroscopic imager suitable for dynamic rat brain imaging of oxygenated hemoglobin concentration and total hemoglobin concentration (HbO, HbT), (2) to develop a 2D tomographic reconstruction algorithm and to obtain 2D dynamic tomography of vascular oxygenation under different oxygen interventions using rat brain tumor phantoms, and (3) to develop and validate, through hemodynamic phantom experiments, mathematical models to quantitatively associates the blood flow (BF) and oxygen consumption rate (O2CR) of the tumor to its HbO and HbT determined by the NIR spectroscopic measurements. After success of the initial R21 development, three specific aims in the R33 phase are: (1) to validate 2D tomographic images of the BF and O2CR using dynamic tumor phantoms, (2) to obtain dynamic images of respiratory-induced changes in HbO, HbT, BF, and O2CR from rat brain tumors (9L Gliosarcoma) before and after radiation therapy with and without carbogen intervention during radiation, and (3) to investigate heterogeneous response of the brain tumors to the intervention and to the radio surgery and to examine the prognostic value of the hemodynamic parameters (Hb, HbO, BF, and O2CR) for the radiation therapy by comparing with the histological analysis of the corresponding tumors.

描述（由申请人提供）： 如果能够在不同治疗阶段对治疗中的肿瘤进行功能监测和成像，这是至关重要且有利的。非常需要一种非侵入性、便携式、经济高效的体内成像工具来选择、指导和跟踪癌症治疗。该分阶段提案的总体目标是开发一种新颖的成像方式，利用近红外（NIR）断层扫描与血流动力学模型相结合，以功能性地获得动物脑肿瘤的血流动力学图像，这些肿瘤在接受或不接受呼吸干预的放射外科手术中。可以无创、长期获得放射外科不同辐射剂量和高氧干预引起的脑肿瘤血红蛋白浓度、血流量和耗氧率变化的断层图像。这种血液动力学图像可以为临床放射外科实践提供关于肿瘤对治疗和干预的不均匀反应以及治疗有效性的预后信息。 R21阶段有三个具体目标：（1）设计和实现8源、8探测器、NIR光谱成像仪，适用于氧合血红蛋白浓度和总血红蛋白浓度（HbO、HbT）的动态大鼠脑成像，（ 2）开发二维断层扫描重建算法，并使用大鼠脑肿瘤模型获得不同氧干预下血管氧合的二维动态断层扫描，以及（3）开发并通过血流动力学模型实验验证数学模型，将肿瘤的血流量 (BF) 和耗氧率 (O2CR) 与近红外光谱测量确定的 HbO 和 HbT 定量关联。在最初的 R21 开发成功后，R33 阶段的三个具体目标是：(1) 使用动态肿瘤模型验证 BF 和 O2CR 的 2D 断层扫描图像，(2) 获得呼吸引起的 HbO 变化的动态图像，放射治疗前后大鼠脑肿瘤（9L 胶质肉瘤）的 HbT、BF 和 O2CR（在放射期间有或没有卡波金干预），以及 (3) 研究大脑的异质反应肿瘤对干预和放射手术的影响，并通过与相应肿瘤的组织学分析进行比较，检查血流动力学参数（Hb、HbO、BF 和 O2CR）对放射治疗的预后价值。