Net Lifetime Health Effects of Alcohol Use & Abuse

饮酒对终生健康的净影响

• 批准号: 7227512
• 负责人: R. Curtis Ellison
• 金额: $ 66.06万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-16 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7227512
• 关键词: Net; Lifetime; Health; Effects; Alcohol

DESCRIPTION (provided by applicant): While the association of alcohol consumption and the risk of many specific disease entities has been investigated in great detail, there are serious deficiencies in knowing the overall relation of alcohol consumption to health and disease throughout the adult lifespan. Given that alcohol has both detrimental and possibly beneficial effects, it is important to know its net effects on the risk of death and of a number of diseases and health conditions that may relate, either positively or inversely, to its use or abuse. We propose to use data collected over 27-55 years among the 10,000+ subjects in the population-based Framingham Study to relate the amount and pattern of alcohol consumption over a large part of their adult lifetime to two of the most important aspects of life: (a) survival (total mortality) and (b) indices of cognitive function. We will also relate alcohol consumption to indices of disability and to a number of other diseases and conditions affected by alcohol intake, including liver disease, accidents, specific cancers, hypertension, coronary disease, stroke, other cardiovascular diseases, seizures, syncope, falls and fractures. The Framingham Study is unique in being able to provide repeated measurements of the amount and pattern of alcohol use and measures of health and disease over what is essentially the entire adult lifespan (until old age for most and until death for more than one half of subjects). The proposed study would carry out an extensive review of health information collected at every encounter with each subject throughout follow up, classify each subject at each encounter according to alcohol consumption (amount and pattern of drinking), identify those with alcohol use disorders, prepare a complete dataset of diseases and causes of death (currently complete only for cardiovascular disease and cancer), and then examine the relation of alcohol use and alcohol use disorders to total mortality (overall and by age strata) and to indices of cognitive function assessed repeatedly over time. The net effects of varying amounts and patterns of drinking would be related to outcomes at different ages. The study will produce a unique dataset and will provide information that should improve our knowledge of the net effects of alcohol throughout adult life.

描述（由申请人提供）：虽然详细研究了饮酒和许多特定疾病实体的风险，但在整个成人寿命中，饮酒与健康和疾病的总体关系的总体关系存在严重的缺陷。鉴于酒精既有害，也可能是有益的影响，因此重要的是要了解其对死亡风险以及许多可能与其使用或滥用相关的疾病和健康状况的净影响。我们建议在基于人群的弗雷明汉研究中使用10,000多名受试者中收集的27 - 55年的数据，以将其成人一生中很大一部分饮酒的数量和模式与生活中最重要的两个方面相关联： （a）生存（总死亡率）和（b）认知功能的指标。我们还将将酒精消耗与残疾指数以及受酒精摄入影响的许多其他疾病和疾病联系起来，包括肝病，事故，特定癌症，高血压，冠状动脉疾病，中风，其他心血管疾病，癫痫发作，癫痫发作，癫痫断裂。 Framingham的研究在能够重复测量酒精使用的数量和模式以及对整个成人寿命上的健康和疾病量度的重复测量（直到大多数年龄段），直到死亡超过一半。 ）。拟议的研究将对每次随访期间每次相遇收集的健康信息进行广泛审查，根据酒精消耗（饮酒的数量和模式）在每次相遇中对每个受试者进行分类，确定患有酒精使用障碍的人，准备一份完整的疾病和死亡原因数据集（目前仅用于心血管疾病和癌症），然后检查酒精使用和酒精使用障碍与总死亡率（总体和按年龄层）以及对认知功能的指标的关系反复评估时间。饮酒量和模式的净影响与不同年龄的结果有关。这项研究将产生独特的数据集，并将提供信息，以提高我们对在成年生活中酒精净影响的了解。

项目成果

The association between alcohol consumption and prevalent cardiovascular diseases among HIV-infected and HIV-uninfected men.

• DOI: 10.1097/qai.0b013e3181c6c4b7
• 发表时间: 2010-02
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Freiberg MS;McGinnis KA;Kraemer K;Samet JH;Conigliaro J;Curtis Ellison R;Bryant K;Kuller LH;Justice AC;VACS Project Team
• 通讯作者: VACS Project Team