Stability of dry powder formulations used in drug delivery to the lungs studied one particle at a time

一次研究一个颗粒用于肺部药物输送的干粉制剂的稳定性

• 批准号: 2886523
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2886523
• 关键词: Stability; dry; powder; formulations; used; Stability; dry; powder; formulations; used

The PhD project will involve the use of a range of conventional tools for characterising formulation performance and stability along with novel single aerosol particle tools developed at the University of Bristol. The specific objectives of the PhD will be to:1. Develop a range of test formulations that exhibit different stability behaviours, characterised by their fine particle aerodynamic performance.2. Assess how changes in storage conditions of the inhalers within a closed secondary pack (e.g., foil overwrap) affect the rate of change.3. Quantify how changes in particulate properties at the microscale may be implicated in these macro level changes.4. Develop models for predicting magnitude of changes over shelf-life.5. Suggest manufacturing control strategy to manage instability.

博士学位项目将涉及使用一系列常规工具来表征配方性能和稳定性，并在布里斯托尔大学开发的新型单烟雾粒子工具。博士学位的特定目标将为：1。开发出一系列表现出不同稳定性行为的测试配方，其特征在于它们的精细颗粒空气动力学性能。2。评估关闭的次要包中吸入器的存储条件的变化（例如，箔覆盖）影响变化速率3。量化如何与这些宏观水平变化有关的颗粒特性的变化。4。开发用于预测保质期变化幅度的模型5。建议制造控制策略以管理不稳定。