WEIGHT, DEPRESSION AND FUNCTIONAL STATUS CHANGE PATHWAYS

体重、抑郁和功能状态变化途径

• 批准号: 6963017
• 负责人: VALERIE HOFFMAN
• 金额: $ 6.64万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6963017
• 关键词: aging; alcoholic beverage consumption; behavioral /social science research tag; body composition; body physical activity; body weight; clinical research; comorbidity; depression; developmental psychology; disease /disorder etiology; functional ability; human data; human middle age (35-64); human old age (65+); longitudinal human study; mental health epidemiology; model design /development; obesity; psychological aspect of aging; psychological models; quality of life; smoking; socioeconomics; statistics /biometry

DESCRIPTION (provided by applicant): The primary goal of the proposed study is to clarify the relationship between changes in weight and depression symptoms over time in the cohort of US adults enrolled in the Health and Retirement Study (HRS). The impact of functional status changes on the relationship between changes in weight and depression symptoms also will be assessed. This study has the following aims: 1. To determine the independent effects of (a) changes in depressive symptoms on changes in body mass index (BMI) and (b) changes in BMI on changes in depressive symptoms, after adjusting for baseline sociodemographic and behavioral factors and for changes in functional status. 2. To determine the degree to which the two relationships described above are modified by changes in functional status or other covariates. 3. To determine whether (a) change in BMI change directly affects change in depression symptom scores or whether the mechanism works indirectly through changes in functional status change and (b) change in depression symptom scores directly affects change in BMI or whether the mechanism works indirectly through functional status change. The immediate objective of the proposed research is to disentangle the relationship between weight and depression symptoms by studying the reciprocal relationship between changes in weight and changes in depression symptoms in the context of changes in functional status. These preliminary analyses will inform the development of future trials to rigorously test whether interventions targeted at reducing symptoms of depression can effectively treat obesity, whether interventions targeted at weight reduction can effectively treat depression, and whether these interventions must be tailored according to functional status. Dr. Hoffman is submitting this application as a new investigator.

描述（由申请人提供）：拟议研究的主要目标是阐明参加健康与退休研究 (HRS) 的美国成年人群体中体重变化与抑郁症状随时间的关系。还将评估功能状态变化对体重变化和抑郁症状之间关系的影响。本研究有以下目的： 1. 在调整基线社会人口统计学和基础数据后，确定 (a) 抑郁症状变化对体重指数 (BMI) 变化的独立影响，以及 (b) BMI 变化对抑郁症状变化的独立影响。行为因素和功能状态的变化。 2. 确定上述两种关系因功能状态或其他协变量的变化而改变的程度。 3. 确定 (a) BMI 变化是否直接影响抑郁症状评分的变化，或者该机制是否通过功能状态变化的变化间接发挥作用，以及 (b) 抑郁症状评分的变化是否直接影响 BMI 的变化，或者该机制是否发挥作用间接通过功能状态改变。 该研究的直接目标是通过研究功能状态变化背景下体重变化和抑郁症状变化之间的相互关系，理清体重和抑郁症状之间的关系。这些初步分析将为未来试验的开展提供信息，以严格测试旨在减轻抑郁症状的干预措施是否可以有效治疗肥胖，旨在减轻体重的干预措施是否可以有效治疗抑郁症，以及这些干预措施是否必须根据功能状态进行调整。 霍夫曼博士作为新研究者提交了这份申请。

项目成果

Impact of functional limitations and medical comorbidity on subsequent weight changes and increased depressive symptoms in older adults.

功能限制和医疗合并症对老年人随后的体重变化和抑郁症状增加的影响。

• 发表时间: 2008-06
• 影响因子: 2.8
• 作者: Forman;Richardson, Kelly K;Yankey, Jon W;Hillis, Stephen L;Wallace, Robert B;Wolinsky, Fredric D
• 通讯作者: Wolinsky, Fredric D

Retirement and weight changes among men and women in the health and retirement study.

健康和退休研究中男性和女性的退休和体重变化。

• 发表时间: 2008-05
• 作者: Forman;Richardson, Kelly K;Yankey, Jon W;Hillis, Stephen L;Wallace, Robert B;Wolinsky, Fredric D
• 通讯作者: Wolinsky, Fredric D

Weight and depressive symptoms in older adults: direction of influence?

老年人的体重和抑郁症状：影响方向？

• 发表时间: 2007-01
• 作者: Forman;Yankey, Jon W;Hillis, Stephen L;Wallace, Robert B;Wolinsky, Fredric D
• 通讯作者: Wolinsky, Fredric D