MR Molecular Imaging using Iron Oxide Nanoparticles

使用氧化铁纳米颗粒进行 MR 分子成像

• 批准号: 7054960
• 负责人: OMAR ZURKIYA
• 金额: $ 3.59万
• 依托单位: GEORGIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-20 至 2007-09-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7054960
• 关键词: bioimaging /biomedical imaging; biomaterial development /preparation; biotechnology; iron oxide; magnetic resonance imaging; molecular probes; predoctoral investigator

DESCRIPTION (provided by applicant): Techniques using targeted and controllable MR probes will be developed to extend the clinical application of iron oxide nanoparticle contrast agents. The project develops: theories and studies of coating characteristics to enhance the effect on the MR signal (Specific Aim 1), controllable and activatable contrast systems (Specific Aim 2), and alternative contrast mechanisms and imaging approaches for positive contrast (Specific Aim 3) to extend the use of MR imaging to acquire information on the molecular level. Such probes allow targeting and delineating areas of specific molecular activity on an MR image. Contrast agents activated under specific, controlled circumstances, such as the expression of a carcinogenic genotype, can be used to obtain images that provide molecular, as well as anatomical information. Applications focused on clinical diagnosis represent a non-invasive tool for health care reducing the need for surgical biopsy which carries health risks, such as morbidity and mortality. For organs where biopsy options are limited, such as the brain, this "virtual biopsy" represents a new tool for clinical management.

描述（由申请人提供）：将开发使用靶向且可控的MR探针的技术来扩展氧化铁纳米粒子造影剂的临床应用。该项目开发：增强对 MR 信号影响的涂层特性的理论和研究（具体目标 1）、可控和可激活对比系统（具体目标 2）以及用于正对比的替代对比机制和成像方法（具体目标 3）扩展 MR 成像的用途以获取分子水平的信息。这种探针可以在 MR 图像上定位和描绘特定分子活性的区域。在特定的受控环境下（例如致癌基因型的表达）激活的造影剂可用于获取提供分子和解剖信息的图像。专注于临床诊断的应用代表了一种非侵入性的医疗保健工具，减少了手术活检的需要，而手术活检会带来发病率和死亡率等健康风险。对于活检选择有限的器官（例如大脑），这种“虚拟活检”代表了临床管理的新工具。