Age-27 Follow-up of Early Preventive Intervention

27 岁早期预防干预的后续行动

基本信息

批准号：
7254690
负责人：
DAVID L OLDS
金额：
$ 47.64万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-28 至 2009-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7254690
关键词：
Adult Age Age-Years Alcohol consumption Behavior Behavioral Birth Birth Intervals Child Child Abuse and Neglect Child Welfare Communication Condition Control Groups Early Intervention Economics Education Effectiveness of Interventions Environmental Risk Factor Expenditure Generations Genes Genetic Genetic Polymorphism Genetic Predisposition to Disease Government Growth Home environment Home visitation House Call Imprisonment Individual Interpersonal Violence Life Cycle Stages Literature Long-Term Effects Low income Marriage Mental Health Methaqualone Military Personnel Mothers New York Nicotine Nurses Occupations Phase Pregnancy Preventive Intervention Productivity Randomized Controlled Trials Rate Receptor Gene Research Risk Running Sampling Social Welfare Substance abuse problem Taxes Tobacco use Training Unmarried Unmarried Mother Violence Visit Visiting Nurse Woman Work Youth assault career comparison group criminal behavior design dopamine transporter employment/unemployment experience fetal tobacco exposure follow-up infancy men prenatal prenatal health programs relationship violence young adult

项目摘要

This study is a longitudinal follow-up of 340 young men and women who have participated in a randomized controlled trial of prenatal and infancy home visiting by nurses in Elmira, New York since their mothers registered in the trial during their pregnancies between 1977 and 1980. The study will be conducted when these first-born children turn 27 years of age. It is designed to determine whether highly promising effects found for nurse home visiting with this sample when these young adults were 15 years of age endure through age 27. Specifically, the current proposal is designed to determine, 25 years after the Elmira program ended at child age 2, whether: 1) nurse-visited young adult offspring differ from comparison-group young adults in: a) their economic productivity (e.g., unemployment, employment in jobs with limited opportunities for career growth, use of welfare; rates of out-of wedlock births); b) the quality of their partnered relationships (rates of interpersonal violence, commitment, and quality of communication); c) their rates of child abuse and neglect perpetrated on their own children; d) their rates of criminal behavior, arrests, convictions, and imprisonment; and e) their mental health and abuse of substances: 2) the effects of the program on the young adults' economic productivity are concentrated on those individuals born to mothers who were low-income and unmarried at registration during their pregnancies; 3) the effects of the program on adult criminality, violent behavior, and second-generation child abuse and neglect, in prcliminary studies, are concentrated on those individuals with genetic vulnerabilities for behavioral dysregulation (functional polymorphisms in the gene that encodes MAOA, the dopamine transporter gene, and the (7 nicotine receptor gene) in combination with environmental risks (prenatal tobacco exposure and child maltreatment); 4) the effect of the program on young adults' adaptive functioning is explained by the combined effects of the program on their mothers" prenatal health-related behaviors, life-course (rates of marriage, subsequent children, and welfare use), and their experience of child abuse and neglect; and 5) nurse-visited young adults produced fewer government expenditures and higher tax revenues compared to young adults assigned to the comparison condition. This study adds to the literature on the long-term effects of early intervention and marks a new phase in this program of research by examining, in preliminary studies, the extent to which the effects of the intervention are concentrated in individuals who are at dual risk for adult criminality because of combined genetic and environmental risks.

这项研究是对 340 名年轻男女的纵向随访，这些年轻男女参加了纽约州埃尔迈拉的一项由护士进行产前和婴儿期家访的随机对照试验，自从他们的母亲在 1977 年至 1980 年间怀孕期间登记参加试验以来。这项研究将在这些第一胎孩子年满 27 岁时进行。它的目的是确定在这些年轻人 15 岁时，对这个样本进行护士家访是否会产生非常有希望的效果，并持续到 27 岁。具体来说，当前的提案旨在确定，在埃尔迈拉计划结束 25 年后，这些年轻人在 15 岁2 岁，是否： 1) 护士拜访的年轻成年后代与对照组年轻成年人的不同之处在于： a) 他们的经济生产力（例如，失业、从事职业发展机会有限的工作、福利的使用；超出率）的婚生）； b) 伴侣关系的质量（人际暴力发生率、承诺和沟通质量）； c) 他们对自己的孩子实施虐待和忽视的比率； d) 他们的犯罪行为、逮捕、定罪和监禁率； e) 他们的心理健康和药物滥用：2) 该计划对年轻人经济生产力的影响集中在低收入母亲所生的人身上。怀孕期间登记时未婚； 3) 在初步研究中，该计划对成人犯罪、暴力行为以及第二代儿童虐待和忽视的影响集中在那些具有行为失调遗传脆弱性的个体（编码 MAOA 的基因中的功能多态性，多巴胺）转运基因和（7 尼古丁受体基因）与环境风险（产前烟草暴露和儿童虐待）相结合；4）该计划对年轻人适应功能的影响可以通过以下因素的综合影响来解释：关于母亲的产前健康相关行为、生命历程（结婚率、后续子女率和福利利用率）以及虐待和忽视儿童经历的方案；以及 5) 护士访视与比较条件下的年轻人相比，年轻人产生的政府支出较少，但税收收入较高。这项研究丰富了有关早期干预长期影响的文献，并通过在初步研究中检查干预效果集中在处于双重风险的个体身上的程度，标志着该研究计划进入了一个新阶段。由于遗传和环境风险相结合而导致的成人犯罪。