Time Domian Electron Paramagnetic Resonance Imaging

时域电子顺磁共振成像

• 批准号: 7292182
• 负责人: murali cherukuri
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7292182
• 关键词: Time; Domian; Electron; Paramagnetic; Resonance

Project 1: Time Domian Electron Paramagnetic Resonance Imaging:Summary:a) Instrumentation: We have developed instrumentation to with data acquisition modalities utilizing "Time-locked sub sampling" strategies. This modality uses low speed data acquisition ( 20 - 100 MHz) to sample high-speed transient data without loss of integrity of the signal quality. The advantage of this modality is that low-cost signal averagers with better dynamic range can be utilized in imaging. Specifically, in imaging experiments, the dynamic range of the image intensity will be significantly improved so that low intensity pixels will be validly represented even in the presence of high intensity regions.b) Digital EPR imaging spectrometer: Until now the EPR imaging instrumentation utilized spectrometers using analog modules. With the recent availability of digital signal processing technology (DSP), we have initiated the implementation of digital version of the EPR Imaging spectrometer. The specific advantages of this effort are that significant reduction in time of image data collection/reconstruction as well as elimination of noise contributions associated with analog components. We completed a test platform and successfully implemented a DSP based EPR imaging spectrometer.c) Graphic User Interface: Since the EPR Imaging spectrometer is an NIH built research spectrometer; the operation of the scanner is fairly complicated and also can be damaged by users unfamiliar with instrumentation. Since most in vivo experiments are carried out by members of the lab with minimal experience with instrumentation, we have developed a graphics user interface (GUI) to make the operation of the scanner for data collection user friendly as well as an additional interface for image reconstruction and display.

项目1：时间Domian电子顺磁共振成像：摘要：a）仪器：我们使用“时锁定的子采样”策略开发了仪器，从而通过数据采集方式开发了仪器。这种模式使用低速数据采集（20-100 MHz）来采样高速瞬态数据，而不会丧失信号质量的完整性。这种方式的优势在于，可以在成像中使用具有更好动态范围的低成本信号。具体而言，在成像实验中，图像强度的动态范围将得到显着改善，以便即使在存在高强度区域的情况下，低强度像素也将有效地表示。B）数字EPR成像光谱仪：到目前为止，EPR成像仪器使用使用Analog模块利用EPR成像仪器使用。随着数字信号处理技术（DSP）的最新可用性，我们启动了EPR成像光谱仪的数字版本的实现。这项工作的具体优势是，图像数据收集/重建时间的显着减少以及消除与模拟组件相关的噪声贡献。我们完成了一个测试平台，并成功实现了基于DSP的EPR成像光谱仪。C）图形用户界面：由于EPR成像光谱仪是NIH构建的研究光谱仪；扫描仪的操作相当复杂，并且不熟悉仪器的用户也可能损坏。由于大多数体内实验是由实验室成员进行的，具有最少的仪器经验，因此我们开发了一个图形用户界面（GUI），以使扫描仪的操作用于数据收集用户友好的数据，以及用于图像重建和显示的其他界面。