Organochlorine pesticide, PCBs, and Parkinsons

有机氯农药、多氯联苯和帕金森病

• 批准号: 7101808
• 负责人: ALBERTO ASCHERIO
• 金额: $ 34.16万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7101808
• 关键词: Parkinson' s disease; Scandinavian country; biomarker; blood tests; chlorohydrocarbon insecticide; clinical research; dichlorodiphenyltrichloroethane; disease /disorder proneness /risk; environmental exposure; halobiphenyl /halotriphenyl compound; hazardous substances; human data; human tissue; longitudinal human study; neuroprotectants; occupational hazard; pesticide biological effect; questionnaires; urate

DESCRIPTION (provided by applicant): We propose to study prospectively whether the risk of Parkinson's disease (PD) is predicted by plasma levels of organochlorine pesticides, polychlorinated biphenyls (PCBs), and the antioxidant uric acid. The proposed investigation will take advantage of a unique population comprising over 35,000 Finnish men and women who provided blood samples in 1968-72 as part of a health examination survey, and have subsequently been followed for incidence of PD for over 20 years. Between the baseline survey and 1994, 201 new cases of PD have been confirmed in this population. Plasma levels of organochlorine insecticides, PCBs, and uric acid will be assessed among these cases and controls matched by age and gender. Specific hypotheses to be tested include: 1) That higher plasma levels of para, para-dichlorodiphenyl dichloroethene [p,p-DDE], the major metabolite of DDT, dieldrin, hexachlorobenzene (HCB), beta-hexachlorocyclohexane (HCH), heptachlor, heptachlor epoxide, trans-nonachlor, and oxychlordane are associated with increase risk of PD; 2) that higher plasma levels of PCBs (sum of all congeners) are associated with an increased risk of PD; and 3) that higher plasma levels of the antioxidant uric acid are associated with a decreased risk of PD, and exert a protective effect against the deleterious effects of DDE. The proposed investigation is unique and innovative as there are no previous data relating biomarkers of exposure to environmental contaminants and future risk of developing PD. The blood samples were collected at a time of high exposure to both organochlorine insecticides and PCBs as supported by the high mean plasma level of DDE and PCBs that we found in a pilot study. Finally, the long follow-up period will allow the investigation of long-term effects of exposure.

描述（由申请人提供）：我们建议对帕金森氏病（PD）的风险进行前瞻性研究。拟议的调查将利用一个独特的人群，其中包括35,000多名芬兰男性和女性，他们在1968 - 72年提供了血液样本，作为健康检查调查的一部分，随后遵循了PD的发病率超过20年。在基线调查和1994年之间，该人群已经确认了201例新的PD病例。在这些病例中，将评估有机氯，PCB和尿酸的血浆水平，以及按年龄和性别匹配的对照。 Specific hypotheses to be tested include: 1) That higher plasma levels of para, para-dichlorodiphenyl dichloroethene [p,p-DDE], the major metabolite of DDT, dieldrin, hexachlorobenzene (HCB), beta-hexachlorocyclohexane (HCH), heptachlor, heptachlor epoxide, trans-nonachlor, and Oxychlordane与PD风险增加有关； 2）较高的血浆PCB水平（所有同源物的总和）与PD风险增加有关； 3）抗氧化剂尿酸的较高血浆水平与PD风险降低有关，并对DDE的有害作用发挥保护作用。拟议的调查是独特而创新的，因为没有以前的数据将暴露于环境污染物的生物标志物以及发展PD的未来风险。我们在一项试点研究中发现的高平均血浆和PCB的支持下，在高暴露于有机氯杀虫剂和PCB的时候收集了血液样本。最后，漫长的随访期将允许调查暴露的长期影响。