Secondary Analysis of Alcohol and Sexual and Injection HIV-risk Behaviors

酒精、性行为和注射艾滋病毒风险行为的二次分析

• 批准号: 7188197
• 负责人: KAMYAR ARASTEH
• 金额: $ 12.02万
• 依托单位: BETH ISRAEL MEDICAL CTR (NEW YORK)
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7188197
• 关键词: AIDS /HIV test; AIDS education /prevention; AIDS therapy; HIV infections; alcoholic beverage consumption; alcoholism /alcohol abuse; antiAIDS agent; behavioral /social science research tag; health care service utilization; high risk behavior /lifestyle; human data; intravenous drug abuse; sex behavior; substance abuse related behavior; therapy compliance

DESCRIPTION (provided by applicant): Alcohol consumption has important implications for the management of the HIV epidemic. Several studies suggest that alcohol use is associated with HIV risk and decreased probability of antiretroviral treatment. However, perhaps because of the prominence of injection risks in HIV infection, the role of alcohol in HIV- related processes in drug users has not been adequately investigated. Addressing this problem is a critical public health concern, because alcohol use is prevalent among drug users, and injection drug users constitutes a large proportion of HIV infections. Our long-term goal is to elucidate the role of alcohol in these HIV-related processes among drug user population. We have an opportunity to analyze data collected in three studies from more than 15,000 drug users that can uniquely illuminate the relation of alcohol to HIV in this population over a period of 14 years of the HIV epidemic and across 14 different national settings. We hypothesize that alcohol use: 1) increases HIV infection risk behaviors, 2) reduces receiving antiretroviral treatment and adherence to it, and 3) shows different patterns of association with risk behaviors over time and across countries. We have five specific aims: 1) Determine the association of alcohol use with sexual risk behaviors, by examining the association of levels of alcohol consumption and sexual risks. 2) Determine the association of alcohol use with injection risk behaviors, by assessing the relation of levels of alcohol consumption with injection risks. 3) Determine the association of alcohol use with HIV testing and probability of antiretroviral treatment. 4) Compare the relation of alcohol use and HIV risk behaviors among injection drug users in a "prevention program rich" environment to "prevention program poor" environment. 5) Determine the relationships between alcohol use and HIV risk behaviors in different developing and transitional countries. This goal of our research is to reduce alcohol-related effects on HIV and as such addresses the mission of the agency. The research would also provide critical information for public health policy regarding the role of alcohol in HIV in both the U.S. and in developing and transitional countries.

描述（由申请人提供）：饮酒对艾滋病毒流行的管理具有重要意义。几项研究表明，饮酒与HIV风险和抗逆转录病毒治疗的可能性降低有关。但是，也许由于艾滋病毒感染中注射风险的突出，酒精在吸毒者中与艾滋病毒相关的过程中的作用尚未得到充分研究。解决这个问题是一个关键的公共卫生问题，因为吸毒者在吸毒者中普遍存在，并且注射吸毒者构成了很大一部分的艾滋病毒感染。我们的长期目标是阐明毒品用户群体中酒精在这些与HIV相关的过程中的作用。我们有机会分析来自15,000多名吸毒者的三项研究中收集的数据，这些数据可以在艾滋病毒流行的14年内以及在14个不同的国家环境中唯一阐明酒精与艾滋病毒的关系。我们假设酒精使用：1）增加艾滋病毒感染风险行为，2）减少接受抗逆转录病毒治疗和遵守的风险行为； 3）显示了随着时间和整个国家的风险行为的不同模式。我们有五个具体的目的：1）通过检查酒精消耗和性风险的关联来确定酒精使用与性风险行为的关联。 2）通过评估饮酒水平与注入风险的关系，确定酒精使用与注射风险行为的关联。 3）确定酒精使用与HIV检测的关联以及抗逆转录病毒治疗的可能性。 4）比较注射吸毒者在“预防计划丰富”环境中的酒精使用和艾滋病毒风险行为与“预防计划”较差的环境的关系。 5）确定不同发展中国家和过渡国家的酒精使用与艾滋病毒风险行为之间的关系。我们研究的目标是减少与酒精相关的艾滋病毒影响，因此解决了该机构的使命。这项研究还将为公共卫生政策提供有关酒精在美国以及发展中国家和发展国家中艾滋病毒中作用的关键信息。