Near Infra Red Energy To Treat Diabetic Neuropathy

近红外能量治疗糖尿病神经病变

• 批准号: 6848587
• 负责人: NIGEL A. CALCUTT
• 金额: $ 14.25万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6848587
• 关键词: afferent nerve; blood circulation; diabetic neuropathy; disease /disorder model; infrared radiation; laboratory rat; motor neurons; nervous system disorder therapy; neurophysiology; nitric oxide; nonhuman therapy evaluation; radiation therapy; streptozotocin; vasodilators

Neuropathy is the most common of the secondary complications associated with diabetes, with over half of all patients developing some form of nerve dysfunction in their lifetime. The etiology of diabetic neuropathy is not well understood and animal models of diabetic neuropathy have been widely used to investigate potential etiologic mechanisms. A number of hypotheses have been presented as a result of such studies, including involvement of increased glucose metabolism by aldose reductase, reduced nerve blood flow, oxidative stress and loss of neurotrophic support and it is becoming clear that many of these mechanisms are interconnected. However, conventional drug-based therapies derived from these mechanisms have yet to be validated in clinical trials and there is still no mechanistically targeted, FDA approved, therapy for diabetic neuropathy. There have been recent reports in the clinical literature that local treatment of limbs with near infra red energy (NIRE) can improve symptoms of neuropathy in diabetic patients. The mechanism of action is not clear, although there is a small scientific literature showing that light energy can have a variety of physiologic effects in mammals, including vasodilation and consequent increases in local blood flow. Because the clinical data demonstrating efficacy of NIRE on diabetic neuropathy is limited and further mechanistic studies may be restricted by technical and ethical considerations, we will perform quantitative studies of the efficacy of NIRE in streptozotocin diabetic rats. This animal model exhibits functional disorders of peripheral nerve that resemble early diabetic neuropathy and is useful for screening potential therapeutic approaches for diabetic neuropathy. We will examine the efficacy of NIRE in preventing and reversing structural, functional and neurochemical disorders of peripheral sensory and motor nerves and have already performed a preliminary study that suggests some efficacy is likely to be confirmed. The purpose of the project is to establish (or dispute) the scientific and mechanistic rationale for the use of NIRE in treating diabetic neuropathy: If efficacy is established, our findings will promote future studies designed to identify plausible mechanisms of action.

神经病变是与糖尿病相关的最常见的继发并发症，超过一半的患者在一生中会出现某种形式的神经功能障碍。糖尿病神经病变的病因尚不清楚，糖尿病神经病变的动物模型已被广泛用于研究潜在的病因机制。这些研究的结果提出了许多假设，包括醛糖还原酶导致的葡萄糖代谢增加、神经血流量减少、氧化应激和神经营养支持丧失，并且越来越清楚的是，这些机制中有许多是相互关联的。然而，源自这些机制的传统药物疗法尚未在临床试验中得到验证，并且仍然没有 FDA 批准的机械靶向治疗糖尿病神经病变的疗法。最近有临床文献报道，用近红外能量（NIRE）对肢体进行局部治疗可以改善糖尿病患者的神经病变症状。尽管有少量科学文献表明光能可以对哺乳动物产生多种生理效应，包括血管舒张和随之而来的局部血流量增加，但其作用机制尚不清楚。由于证明 NIRE 对糖尿病神经病变疗效的临床数据有限，并且进一步的机制研究可能受到技术和伦理考虑的限制，我们将进行 NIRE 对链脲佐菌素糖尿病大鼠疗效的定量研究。该动物模型表现出类似于早期糖尿病神经病变的周围神经功能障碍，可用于筛选糖尿病神经病变的潜在治疗方法。我们将研究 NIRE 在预防和逆转周围感觉和运动神经的结构、功能和神经化学疾病方面的功效，并且已经进行了一项初步研究，表明一些功效可能得到证实。该项目的目的是确定（或质疑）使用 NIRE 治疗糖尿病神经病变的科学和机制原理：如果疗效确定，我们的研究结果将促进未来旨在确定合理作用机制的研究。