Pre-diagnostic markers of infection and risk of MS

感染和多发性硬化症风险的预诊断标记

• 批准号: 7265149
• 负责人: ALBERTO ASCHERIO
• 金额: $ 35.96万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7265149
• 关键词: Address; Antibodies; Antigens; Appearance; Blood specimen; Capsid; Case Study; Case-Control Studies; Chlamydophila pneumoniae; Clinical; Collection; Complex; Cytomegalovirus; Department of Defense; Diagnostic; Documentation; Epstein-Barr Virus Infections; Epstein-Barr Virus Nuclear Antigens; Ethnic Origin; Funding; Gender; Hepatitis A Virus; Herpesviridae; Human; Human Herpesvirus 4; Immune; Immunoglobulin G; Immunoglobulin M; Indirect Immunofluorescence; Individual; Infection; Investigation; Marines; Measures; Military Personnel; Multiple Sclerosis; Myelin Associated Glycoprotein; Myelin Basic Proteins; Neurologic; Numbers; Relapsing-Remitting Multiple Sclerosis; Risk; Risk Marker; Sample Size; Sampling; Serological; Serum; Symptoms; Time; Viral; Viral Load result; Virus Diseases; follow-up; oligodendrocyte-myelin glycoprotein; prospective; repository; viral DNA

DESCRIPTION (provided by applicant): We propose to continue and expand our ongoing prospective investigation on prediagnostic serological markers of infection and risk of MS. During the first period of this project, we have found evidence that a significant increase in serum antibodies to the Epstein-Barr Virus (EBV) occurs years before the onset of the first symptoms of multiple sclerosis (MS). In contrast, serum titers of anti-Chlamydia pneumoniae (Cpn) were not significantly related to risk of MS. We now propose to expand our findings on EBV, to extend the investigation to human herpes virus 6 (HHV-6) and the hepatitis A virus, and to examine whether the presence of IgM antibodies to myelin oligodendrocyte glycoprotein (MOG) or myelin basic protein (MBP) in asymptomatic individuals predicts the risk of MS. The proposed investigation will continue to take advantage of the Department of Defense Serum Repository, a unique facility now comprising multiple serum samples collected from over 7 million US military personnel. In the first project period, we have only included in the study cases and controls from the Army. To increase the power of the study, we will now extend the identification of MS cases and selection of controls to the Navy. By this mean, and by extending the follow up for case identification to the year 2007, we expect to increase the number of cases to 501 and to extend the interval between the date of collection of the first blood samples to the onset of the first MS symptoms to over 10 years. This large sample size and the availability for each subject of serum samples collected at multiple points in time will allow sufficient power to examine the relationship between changes in the serological markers and risk of developing MS.

描述（由申请人提供）：我们建议继续并扩大我们正在进行的对诊断性血清学标志物感染和MS风险的前瞻性调查。在该项目的第一个阶段，我们发现证据表明，在多发性硬化症（MS）首次发作之前的几年之前，发生了几年前，对爱泼斯坦 - 巴尔病毒（EBV）的血清抗体显着增加。相比之下，肺炎（CPN）的血清滴度与MS的风险无关。现在，我们建议扩大在EBV上的发现，将研究扩展到人疱疹病毒6（HHV-6）和肝炎A病毒，并检查是否存在IgM抗髓磷脂的抗体抗体抗体的存在。 （MBP）在无症状的个体中预测了MS的风险。拟议的调查将继续利用国防部的血清存储库，这是一个独特的设施，现在包括从700万美国军事人员那里收集的多个血清样本。在第一个项目时期，我们仅包括研究案例和陆军对照。为了提高研究的力量，我们现在将将MS病例的识别和对照选择扩展到海军。按照这种均值，并将病例识别的后续行动扩展到2007年，我们希望将病例数增加到501，并将收集第一批血液样本日期之间的间隔扩展到第一个MS的发作症状超过10年。这个较大的样本量以及在多个时间点收集的每个血清样品的可用性将允许足够的功率检查血清学标记变化与发展MS的风险之间的关系。