NEUROPATHOLOGY CORE

神经病理学核心

• 批准号: 6933611
• 负责人: MARLA GEARING
• 金额: $ 9.74万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6933611
• 关键词: Alzheimer' s disease; apolipoprotein E; biochemistry; biomedical facility; cognition disorders; freezing; genotype; human genetic material tag; human tissue; method development; molecular genetics; neuropathology; postmortem; tissue resource /registry

The primary goal of the Neuropathology Core is to promote and support research on mild cognitive impairment (MCI), Alzheimer's disease and other neurodegenerative disorders through banking and distribution of well-characterized tissue coupled with comprehensive neuropathologic assessment of ADC registry cases coming to autopsy. To best achieve this goal, the Emory ADC will work in partnership with the Neuropathology Core of the Indiana University ADC. The combined resources of the two institutions and their unique strengths create a synergistic relationship that will build upon already existing inter-institutional collaborations, enhance the capabilities of both institutions, and support the achievement of the primary goal of the Neuropathology Core through the following activities: (1) Comprehensive neuropathologic, biochemical and molecular genetic assessment of autopsy brains from dementia patients, controls and subjects with mild cognitive impairment. This assessment includes characterization of the heterogeneity of AD and dementias associated with other neurologic disorders (e.g., Parkinson's disease and Lewy body dementia, frontotemporal dementias, and vascular disease). (2) Generation of reliable neuropathologic data for correlation with information collected by the Clinical Core and for use in research studies at Emory University, Indiana University, and other institutions. (3) Maintenance of an active tissue bank to facilitate the acquisition, storage, handling, and distribution of well-characterized autopsy brain tissue, DMA, and other biological samples. (4) Determination of ApoE genotype on all blood samples accessioned by the Clinical Core and on all autopsy cases accessioned by the Neuropathology Core, molecular genetic analysis of other genes associated with neurodegenerative disease, and facilitation of collaborative investigations using the Neuropathology Core's bank of DNA extracts, plasma samples, and buffy coat isolates generated during the genotyping process.

神经病理学核心的主要目的是通过银行和分布良好的特征性组织的银行和分布，以及对ADC Registr的全面神经病理评估，促进和支持对轻度认知障碍（MCI），阿尔茨海默氏病和其他神经退行性疾病的研究。为了最好地实现这一目标，Emory ADC将与印第安纳大学ADC的神经病理学核心合作。这两个机构的综合资源及其独特的优势创造了协同关系，这将基于已经存在的机构间 通过以下活动，合作，增强了这两个机构的能力，并支持神经病理学核心的主要目标：（1）全面的神经病理学，生化和分子遗传评估对痴呆症患者，对照和轻度认知障碍的受试者的尸检大脑的尸检。该评估包括表征与其他神经系统疾病相关的AD和痴呆症的异质性（例如帕金森氏病和刘易体内痴呆，额颞痴呆和血管疾病）。 （2）生成可靠的神经病理数据，以与临床核心收集的信息相关联，用于在Emory的研究中使用 大学，印第安纳大学和其他机构。 （3）维护活性组织库，以促进良好的尸检脑组织，DMA和其他生物样品的获取，存储，处理和分布。 （4）确定由临床核心康复的所有血液样本和神经病理学核心康复的所有尸检病例，与神经退行性疾病相关的其他基因的分子遗传分析的确定，并促进了使用协作研究。 神经病理学核心的DNA提取物，血浆样品和基因分型过程中产生的Buffy Coat分离株。