GENETIC EPIDEMIOLOGY OF SARCOIDOSIS IN AFRICAN AMERICANS

非裔美国人结节病的遗传流行病学

• 批准号: 7181274
• 负责人: MICHAEL C IANNUZZI
• 金额: $ 0.44万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7181274
• 关键词: biomedical resource; clinical research; genetics

DESCRIPTION (provided by applicant): This Human Genetic Analysis Resource will facilitate the mapping, identification and characterization of genes that cause complex diseases in man. The Resource will provide services and expertise in human genetic analysis to research workers investigating the familial nature of such diseases. Further statistical methods of analysis and study designs will be developed for this purpose, and well-documented, user-friendly computer programs prepared that can be easily tailored to the needs of human geneticists and genetic epidemiologists. Theoretical developments will include studies of validity, power and robustness of all procedures developed. Methods of association, segregation and linkage analysis will allow for, e.g., nonnormality, multifactorially caused familial correlations, measured and non-measured environmental effects, both Mendelian and non-Mendelian genetic effects, and non-random sampling. Consulting services in the use of these methods will be provided, and the methods will be applied in collaborative research to several broad areas, including cancer, pulmonary/cardiovascular diseases, ophthalmologic diseases, neurological diseases, autoimmune diseases, renal diseases, and dental/craniofacial phenotypes. Human genetic analysts will be trained at the pre- and post-doctoral levels, and short courses given, both nationally and internationally, to train people in statistical analysis for genetic epidemiology and in the use of the computer programs that will be developed. Information about the Resource and its activities will be broadly disseminated at national and international meetings and by maintaining a home page on the World Wide Web.

描述（由申请人提供）：这种人类遗传分析资源将促进对人类引起复杂疾病的基因的映射，识别和表征。 该资源将在人类遗传分析方面提供服务和专业知识，以研究调查此类疾病家族性质的研究工作者。 为此目的，将开发进一步的分析和研究设计方法，并有据可查，用户友好的计算机程序，可以轻松地根据人类遗传学家和遗传流行病学家的需求量身定制。 理论发展将包括有关开发所有程序的有效性，权力和鲁棒性的研究。 关联，分离和连锁分析的方法将允许，例如非正态，多因素引起的家族相关性，测量和非测量的环境效应，包括孟德尔和非孟德尔遗传效应以及非随机抽样。 将提供这些方法的咨询服务，并将这些方法在协作研究中应用于多个广泛领域，包括癌症，肺/心血管疾病，眼科疾病，神经系统疾病，自身免疫性疾病，肾脏疾病，肾脏/颅内/颅骨疾病。 人类遗传分析师将在博士后和博士后培训，并在国内和国际上进行简短的课程，以培训人们在统计分析中培训遗传流行病学的统计分析以及将开发将要开发的计算机程序。 有关资源及其活动的信息将在国家和国际会议上广泛传播，并通过在万维网上维护主页。