Development of a Telemetric Monitor for IOP

眼压遥测监测仪的开发

• 批准号: 7162035
• 负责人: J CRAWFORD DOWNS
• 金额: $ 18.36万
• 依托单位: LEGACY EMANUEL HOSPITAL AND HEALTH CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162035
• 关键词: Macaca mulatta; bioengineering /biomedical engineering; biomedical equipment development; clinical biomedical equipment; computer program /software; computer system design /evaluation; glaucoma; implant; intraocular pressure; laboratory rabbit; longitudinal human study; optic nerve; optic nerve disorder; telemetry

DESCRIPTION (provided by applicant): The purpose of the present proposal is to develop and implement a telemetric IOP monitoring system that can be used to obtain continuous, round-the-clock IOP data over long periods of time. Telemetric 24-hour IOP characterization is important for two reasons. First, it will lay the foundation for experimental, computational, and theoretical studies to investigate individual optic nerve head susceptibility to IOP. Second, it will lay the foundation for telemetric IOP monitoring of glaucoma patients and the clinical achievement of true, 24-hour intraocular pressure control. The Specific Aims and Objectives are 1) to develop a telemetric IOP monitor; 2) to develop the software necessary to visualize and characterize telemetric 24-hour IOP data; and 3) to use the hardware and software developed in Specific Aims 1 and 2 to capture and characterize 24-hour IOP data over a 6-month period. The Methodology includes modifying an existing subcutaneous, battery-powered, implantable pressure monitor of proven design (DISS T-27-F series implant) by integrating the transducer into an LSD-designed, extraocular, sclera-fixated, silicone baseplate that is connected to the anterior chamber via a silicone tube. Hardware and software associated with the DISS system will be specifically optimized for the capture, visualization, and quantification of 24-hour IOP data. Custom, automated algorithms for visualizing and quantifying the IOP levels to which the eye is exposed over time will be developed and implemented in software. The system's ability to accurately capture the pattern of diurnal IOP fluctuation (magnitude, frequency, and duration) will be characterized, as will its ability to accurately record short-term IOP fluctuations as in the case of blink and eye rub. The goal is to provide a mature, turnkey solution for long-term (minimum 12 month), 24-hour, telemetric IOP monitoring. Such a system will advance glaucoma research and yield valuable insight into the role of IOP in the development and progression of glaucomatous optic neuropathy.

描述（由申请人提供）：本提案的目的是开发和实施一种遥测眼压监测系统，该系统可用于长时间获取连续、全天候的眼压数据。遥测 24 小时 IOP 表征非常重要，原因有两个。首先，它将为研究个体视神经乳头对眼压的敏感性的实验、计算和理论研究奠定基础。其次，将为青光眼患者遥测眼压监测和临床实现真正的24小时眼压控制奠定基础。 具体目的和目标是 1) 开发遥测眼压监测仪； 2) 开发可视化和表征遥测 24 小时 IOP 数据所需的软件； 3) 使用特定目标 1 和 2 中开发的硬件和软件来捕获和表征 6 个月内的 24 小时 IOP 数据。 该方法包括通过将传感器集成到 LSD 设计的眼外巩膜固定硅胶基板（连接到通过硅胶管进入前房。与 DISS 系统相关的硬件和软件将专门针对 24 小时 IOP 数据的捕获、可视化和量化进行优化。用于可视化和量化眼睛随时间所暴露的眼压水平的定制自动化算法将在软件中开发和实施。该系统准确捕捉昼间 IOP 波动模式（幅度、频率和持续时间）的能力将得到表征，其准确记录短期 IOP 波动（如眨眼和揉眼）的能力也将被表征。 目标是为长期（至少 12 个月）、24 小时遥测 IOP 监测提供成熟的交钥匙解决方案。这样的系统将推进青光眼研究，并为 IOP 在青光眼视神经病变的发生和进展中的作用提供有价值的见解。