Center for Biologic Basis of Oral/Systemic Diseases (CB*

口腔/全身疾病生物学基础中心 (CB*

• 批准号: 6951620
• 负责人: Jeffrey L Ebersole
• 金额: $ 218.26万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-23 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6951620
• 关键词: clinical research; human subject; oral bacteria; periodontitis

DESCRIPTION (provided by applicant): The objectives of the Center for the Biologic Basis of Oral/Systemic Diseases (CBBOSD) are: RESEARCH: To develop a better understanding of the biologic principles that underpin the observed linkages of chronic oral infections and inflammation with systemic disease sequelae; and TRAINING: To use this research focus as a platform to develop promising young investigators in oral health sciences and enhance their competitiveness for external funding, including NIH grant support. We will accomplish these objectives by: Organizing a cadre of established, funded scientists to examine crucial questions related to oral and systemic health linkages, Providing young research faculty with opportunities for interdisciplinary training in oral health sciences and systemic disease, Mentoring young faculty in research projects focused on oral infections, host responses, and systemic disease that will lead to success as independent NIH-funded researchers, Developing and supporting core facilities and resources to optimize the research enterprise of the CBBOSD faculty, Facilitating pilot projects, as well as intra- and inter-university collaborations among CBBOSD faculty, and other researchers at the University of Kentucky, Strategic hiring of new faculty to complement existing strengths to contribute to a critical mass of funded investigators in the biology of oral-systemic diseases. To address this need, we have organized the research activities and leadership of the CBBOSD into 2 broad thematic areas. These thematic areas will incorporate 6 research projects that are integrated with respect to underlying concepts, methodologies, and availability of biological specimens. THEMATIC AREA 1: Oral infections: Translational studies of hostparasite interactions; Project 1: Oral Infections and HIV Recrudescence; Project 2: Oral Infections: Inflammation, Lipid Metabolism, and Atherosclerosis; Project 3: Oral Infections: Genomic Analysis of Host Responses to Polyrnicrobial Infections;. THEMATIC AREA 2: Oral infections: Clinical implications for systemic disease; Project 4: Oral Infections: Impact on Gestational Diabetes; Project 5: Oral Infections: Dietary Regulation of Local and Systemic Inflammatory Responses; Project 6: Oral Infections: Viral/Bacterial Interactions in Chronic Diseases. These research projects are integral to the goals of the CBBOSD because they focus on critical questions of the biology of chronic oral infections and contribution to alterations in systemic health. The overall focus of the CBBOSD is diverse to enable this interdisciplinary research team to: (i) address the myriad of challenges in understanding critical parameters of the interplay between infections and disease in the oral cavity, and (ii) use the available expertise of senior faculty at UK with experience in mentoring young investigators. Thus, junior investigators will be integrated into research projects with established, funded faculty who use state-of-the-art cellular and molecular approaches to explore the biologic basis of this relationship. The breadth of science and varied senior research expertise assures that the CBBOSD will provide opportunities for many junior investigators, who will have the capability to interact within this nurturing environment. The outcomes of this mentored, nurturing structure will enhance the maturation of oral health research at UK, through the College of Dentistry, and synergize in expanding NIH-funded research in the Commonwealth of Kentucky.

描述（由申请人提供）： 口腔/全身疾病生物学基础中心 (CBBOSD) 的目标是： 研究：更好地理解支持慢性口腔感染和炎症与全身疾病后遗症之间观察到的联系的生物学原理；培训：利用这一研究重点作为平台，培养口腔健康科学领域有前途的年轻研究人员，并提高他们获得外部资金（包括 NIH 拨款支持）的竞争力。我们将通过以下方式实现这些目标： 组织一支由受资助的知名科学家组成的骨干队伍，研究与口腔和全身健康联系相关的关键问题； 为年轻研究人员提供口腔健康科学和全身疾病跨学科培训的机会； 指导年轻研究人员参与研究项目专注于口腔感染、宿主反应和全身性疾病，这些将导致美国国立卫生研究院资助的独立研究人员取得成功，开发和支持核心设施和资源，以优化 CBBOSD 教师的研究事业，促进试点项目，以及CBBOSD 教职人员和肯塔基大学其他研究人员之间的校内和校际合作，战略性聘用新教职人员以补充现有优势，为口腔系统疾病生物学领域的受资助研究人员做出重要贡献。为了满足这一需求，我们将 CBBOSD 的研究活动和领导分为 2 个广泛的主题领域。这些主题领域将包含 6 个研究项目，这些项目在基本概念、方法和生物标本的可用性方面进行了整合。主题领域 1：口腔感染：宿主寄生虫相互作用的转化研究；项目1：口腔感染和艾滋病毒复发；项目2：口腔感染：炎症、脂质代谢和动脉粥样硬化；项目 3：口腔感染：宿主对多微生物感染反应的基因组分析；。主题领域 2：口腔感染：对全身性疾病的临床意义；项目 4：口腔感染：对妊娠期糖尿病的影响；项目5：口腔感染：局部和全身炎症反应的饮食调节；项目 6：口腔感染：慢性疾病中的病毒/细菌相互作用。这些研究项目是 CBBOSD 目标的组成部分，因为它们专注于慢性口腔感染生物学的关键问题以及对改变全身健康的贡献。 CBBOSD 的总体重点是多样化的，以使这个跨学科研究团队能够：（i）解决理解口腔感染与疾病之间相互作用的关键参数方面的无数挑战，以及（ii）利用高级专家的现有专业知识英国的教师在指导年轻研究者方面拥有丰富的经验。因此，初级研究人员将与已建立的、受资助的教师一起参与研究项目，他们使用最先进的细胞和分子方法来探索这种关系的生物学基础。科学的广度和多样化的高级研究专业知识确保 CBBOSD 将为许多初级研究人员提供机会，他们将有能力在这个培育环境中进行互动。这一指导性培育结构的成果将通过牙科学院促进英国口腔健康研究的成熟，并协同扩大肯塔基州国家卫生研究院资助的研究。