COBRE: UOK HSC: P1: MICROBIAL MEDIATORS OF TISSUE CELL BEHAVIOR

COBRE：UOK HSC：P1：组织细胞行为的微生物介质

• 批准号: 7171230
• 负责人: JOHN J DMYTRYK
• 金额: $ 10.74万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171230
• 关键词: biofilm; clinical research; health science research support; oral bacteria

DESCRIPTION (provided by applicant): The present Center of Biomedical Research Excellence (COBRE) proposal is designed to grow oral health related research, and increase the competitiveness of investigators associated with the University of Oklahoma College of Dentistry and affiliated institutions with common interests in dental research. At the center of this proposal are the junior investigators who will take a multidisciplinary approach to study microbial biofilm formation and metabolism on natural and artificial dental surfaces. The establishment and evolution of microbial biofilms on smooth surfaces in the oral cavity leads to dental caries, gingivitis, and periodontitis, accounting for the majority of all dental disease. To approach this problem from a number of vantage points, project investigators in the present proposal were drawn from complementary fields, including microbiology and genetics, pathology and cell biology, periodontics, and dental materials. An administrative core will oversee and work with the junior investigators, providing mentoring from senior investigators, enhanced core facilities, and an external advisory committee of internationally recognized scientists in the thematic topic of microbial biofilms on dental surfaces. In addition, a training program for students at all levels will be initiated as well as an outreach program to identify faculty and students at other institutions in the state interested in dental biofilm research. The university administration has committed to expand this effort with the addition of two permanent faculty positions from institutional resources. This COBRE proposal provides the necessary resources, infrastructure, and mentoring required for Oklahoma dental researchers to be successful in competing for future NIH funding as independent investigators. The ultimate benefit of this program will be the translation of research knowledge to treatment and prevention of oral diseases.

描述（由申请人提供）： 目前的生物医学研究中心卓越（COBRE）提案旨在发展与口腔健康相关的研究，并提高与俄克拉荷马大学牙科学院的研究人员的竞争力，以及具有牙科研究中共同利益的附属机构。 该提案的中心是初级研究人员，他们将采用多学科方法来研究自然和人造牙齿表面上的微生物生物膜形成和代谢。微生物生物膜在口腔平滑表面上的建立和演变导致龋齿，牙龈炎和牙周炎，这占所有牙齿疾病的大部分。为了从许多优势点解决这个问题，本提案中的项目研究人员是从互补领域中得出的，包括微生物学和遗传学，病理学和细胞生物学，牙周和牙科材料。行政核心将与初级调查人员一起监督和合作，从而提供高级研究人员，增强核心设施的指导，以及在牙齿表面的微生物生物膜主题中，国际公认的科学家的外部咨询委员会。此外，将启动针对各级学生的培训计划，以及一项外展计划，以确定对牙科生物膜研究感兴趣的州其他机构的教师和学生。大学行政部门已致力于扩大这项工作，并增加了两个永久教师职位，从机构资源中增加了。该脚底提案提供了俄克拉荷马州牙科研究人员成功竞争未来NIH资金所需的必要资源，基础设施和指导。该计划的最终好处将是将研究知识转化为治疗和预防口腔疾病。