PLANNING GRANT FOR RESEARCH ON BLINDING EYE DISEASES

盲眼疾病研究计划拨款

• 批准号: 7171442
• 负责人: Darlene A Dartt
• 金额: $ 72.73万
• 依托单位: SCHEPENS EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171442
• 关键词: angiogenesis; blindness; clinical research; comorbidity; experimental designs; eye disorder; health science research; inflammation; interdisciplinary collaboration; meeting /conference /symposium; microorganism toxin; pathologic process; retina; uvea; wound healing

DESCRIPTION (provided by applicant): The high degree of specialization within ophthalmology has limited the flow of information and ideas from other disciplines. Motivated by the fact that many blinding diseases have mechanistically related pathologies in other organ systems, a diverse group of experts drawn from both vision and non-vision sciences, primarily from Harvard Medical School, propose to form a cluster of interdisciplinary teams to identify new strategies for addressing a spectrum of blinding eye diseases. Teams will be formed around cellular and molecular mechanisms that lead to blindness, but that also have corollary disease processes in other organ systems. The mechanisms include disordered angiogenesis, dysregulated inflammation, aberrant wound healing, and microbial toxin-induced pathology. The overall goal of this effort is to develop novel hypotheses to explain the pathogenesis of blinding eye diseases for which no cures or treatments now exist, and to design an Interdisciplinary Center to pursue these hypotheses. This goal will be achieved by accomplishing the following: 1) For Year 1 the goal is to develop a set of new hypotheses for the pathogenesis of blinding eye diseases resulting from disordered angiogenesis, dysregulated inflammation, aberrant wound healing, and microbial toxin-induced pathology. This will be accomplished via a series of large and small workshops that will bring together scientists of varied disciplines. A large symposium will assemble top experts in research on blinding eye diseases, and in corollary diseases, to acquaint each other with the current state of knowledge. This meeting will be followed by smaller, more specialized exploratory workshops to allow in depth discussion of the similarities and differences between ocular diseases and their non-ocular counterparts, with particular emphasis on their multifactorial pathogenesis. 2) In Year 2 the workshop format will be used to identify pilot projects to be conducted to test the validity of hypotheses advanced. There will be focus on identifying emerging technologies and educational workshops will be organized to bring these new technologies to the problem of blinding diseases of the eye. 3) During Year 3 results of the pilot projects will be reviewed and validity of the hypotheses assessed in order to identify cross cutting interdisciplinary programs that are most likely to advance knowledge on the pathogenesis of blinding diseases. Based on these findings, an application for an Interdisciplinary Center for Research on Blinding Eye Diseases will be prepared.

描述（由申请人提供）： 眼科中的高度专业化限制了其他学科的信息和思想的流程。由于许多盲目疾病在其他器官系统中具有机理相关的病理学，这是一个事实，这是一群来自视觉和非视觉科学的专家组，主要来自哈佛医学院，建议组成一组跨学科团队，以确定针对盲目眼疾病范围的新策略。团队将围绕导致失明的细胞和分子机制形成，但在其他器官系统中也具有推论疾病过程。这些机制包括无序的血管生成，失调的炎症，异常伤口愈合以及微生物毒素诱导的病理学。这项工作的总体目标是开发新的假设，以解释目前不存在治愈或治疗的盲目眼病的发病机理，并设计一个跨学科的中心来追求这些假设。将通过完成以下操作来实现此目标：1）对于1年，目标是为盲目的血管生成，炎症失调，异常伤口愈合和微生物毒素诱导的病理学而产生的一组新假设，以构成盲目眼病的发病机理。这将通过一系列大型小型研讨会来完成，这些研讨会将汇集各种学科的科学家。大型研讨会将汇集有关盲目疾病和推论疾病研究的顶级专家，以相互了解当前的知识状态。在这次会议之后，将进行较小，更专业的探索性研讨会，以深入讨论眼部疾病及其非眼疾病之间的相似性和差异，并特别强调其多因素发病机理。 2）在第2年，研讨会格式将用于确定要进行的试点项目，以测试假设的有效性。将重点放在识别新兴技术上，并将组织教育研讨会，以使这些新技术成为眼睛盲目疾病的问题。 3）在第3年期间，将审查试点项目的结果，并评估了所评估的假设的有效性，以确定跨学科的跨学科计划，这些计划最有可能促进有关盲目疾病发病机理的知识。基于这些发现，将准备针对盲目眼病研究中心的申请。