Lung/Colon Cancer Outcomes--Cancer Research Network

肺癌/结肠癌结果--癌症研究网络

• 批准号: 6806580
• 负责人: JANE C. WEEKS
• 金额: $ 169.18万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-18 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6806580
• 关键词: age difference; clinical research; colorectal neoplasms; health science research analysis /evaluation; human subject; interview; lifestyle; longitudinal human study; lung neoplasms; medical records; neoplasm /cancer epidemiology; outcomes research; racial /ethnic difference; rural area; socioeconomics; urban area

DESCRIPTION (provided by applicant): We will accrue all patients with newly diagnosed lung or colon cancer receiving their care in one of five geographically diverse sites in the Cancer Research Network, an NCI-funded research consortium of HMOs. Automated data for all patients (2,058 patients with lung cancer over the two year enrollment period, and 1,732 patients with colon cancer over the two year enrollment period) will be supplemented with data obtained from complete medical record review and patient surveys for a sample of 1,424 patients with newly diagnosed lung cancer and 1,222 patients with newly diagnosed colon cancer. We will oversample African-Americans, Asians and Pacific Islanders, as well as Medicaid recipients. In addition, we will assemble an inception cohort of patients with newly diagnosed metastatic recurrences of colorectal cancer during the two-year enrollment period (projected at approximately 300 patients) for comprehensive data collection. We propose to lead analyses of CanCORS-wide core data in order to (1) examine the effect of race and ethnicity on patterns of care, treatment choice, quality of life, symptom control, and satisfaction; (2) characterize the types of providers seen by patients and examine the associations between provider characteristics/attitudes and patterns of care and outcomes; (3) evaluate the relationship between the structure/function of cancer care in the health care delivery systems of participating patients and patient outcomes, including health status, patient satisfaction, and cost; and (4) generate estimates of utility weights and time- and out-of-pocket costs that are disease- and treatment-specific for use in future cost-effectiveness analyses. Finally, in a Special Research Study we will aggregate cost data for CRN CanCORS subjects in order to (1) determine cancer-attributable phase-specific and lifetime costs of care for colorectal and lung cancer; (2) determine the proportion of total cancer-attributable costs that are spent on initial therapy versus second- and third line therapies for each cancer, stratified by stage at diagnosis; and (3) determine the relationship between type of initial therapy and the subsequent lifetime cancer-attributable costs of care.

描述（由申请人提供）： 我们将收集所有新诊断的肺癌或结肠癌患者 在癌症中心五个不同地理位置的地点之一接受护理 Research Network，一个由 NCI 资助的 HMO 研究联盟。自动化数据 对于所有患者（入组两年内有 2,058 名肺癌患者 两年内招募了 1,732 名结肠癌患者 期间）将补充从完整医疗记录中获得的数据 对 1,424 名新诊断患者的样本进行审查和患者调查 肺癌和 1,222 名新诊断结肠癌患者。我们将 对非裔美国人、亚洲人和太平洋岛民进行过度采样，以及 医疗补助受益人。此外，我们将组建一个初始队列 新诊断结直肠癌转移性复发的患者 在两年的入学期间（预计大约有 300 患者）进行全面的数据收集。我们建议主导分析 CanCORS 范围内的核心数据，以便 (1) 检查种族和 种族对护理模式、治疗选择、生活质量、症状的影响 控制力和满意度； (2) 描述所看到的提供者类型 患者并检查提供者之间的关联 护理和结果的特征/态度和模式； (3) 评估 医疗保健中癌症护理的结构/功能之间的关系 参与患者的输送系统和患者结果，包括 健康状况、患者满意度和费用； (4) 生成估计值 效用权重以及疾病和自付费用 特定治疗用于未来的成本效益分析。最后，在 一项特别研究，我们将汇总 CRN CanCORS 科目的成本数据 为了 (1) 确定癌症归因的阶段特异性和寿命 结直肠癌和肺癌的护理费用； (2)确定比例 初始治疗花费的总癌症归因费用与 每种癌症的二线和三线疗法，按阶段分层 诊断; (3) 确定初始治疗类型之间的关系 以及随后的终生癌症相关护理费用。