COBRE: U NEL: P5: MACROMOLECULAR CRYSTALLOGRAPHY: ENZYM/CRYSTALLOG GSH ENZYMES

COBRE：U NEL：P5：大分子晶体学：酶/晶体 GSH 酶

• 批准号: 7171060
• 负责人: JOSEPH J BARYCKI
• 金额: $ 14.12万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171060
• 关键词: cooperative study; health science research support; interdisciplinary collaboration; oxidation reduction reaction

DESCRIPTION (provided by applicant): This IDeA proposal presents a detailed plan to create a rnultidisciplinary Center for Biomedical Research Excellence (COBRE) in Nebraska for Redox Biology. The Center will link scientists at the two leading research-active institutions in the state - the UN-Lincoln and the UNMC - in a collaborative pursuit to unravel fundamental problems in redox biology that impact the pathogenesis of a number of diseases including some cancers, arthritis and cardiovascular diseases and the progression of natural phenomena such as aging. The objectives of the proposed Center are (i) to enhance biomedical research capacity in the state by creating an infrastructure that will strategically link strong research programs in redox biology at the two institutions and (ii) to mentor a cadre of junior faculty to independent funding success at NIH. These objectives will be met by providing a rich and rigorous mentoring environment for junior investigators, by bolstering core facilities, by fostering collaborations among scientists at both institutions and by recruiting five additional faculty members with research interests in the area of redox biology to ensure the critical mass of scientists necessary to sustain a nationally visible and internationally recognized Center. A key design feature for the organization of the Center is the mentoring of each of the five developing faculty members by an established investigator with similar research interests and a successful track record of funding at NIH. As these project leaders transition to funding independence, their projects will be replaced by ones led by the newly recruited faculty members. A Director with the vision, scientific expertise and administrative experience necessary to provide effective leadership will be primarily responsible for steering the Center. She will be counseled by members of the Mentoring Council, comprising five established scientists at the Nebraska institutions, and guided by an External Advisory Council (EAC) comprising eight outstanding scientists, five of whom are members of the National Academy of Sciences, and all of whom have agreed to serve in this capacity. The synergistic environment resulting from the creation of the Center will enrich the culture of research in the state, will enliven its community of biomedical scientists and will elevate the quality and offerings of key core facilities.

描述（由申请人提供）：该想法提案提出了一个详细的计划，以创建内布拉斯加州内布拉斯加州氧化还原生物学的生物医学研究卓越研究中心（Cobre）。该中心将在该州的两个领先的研究活性机构（UN -Lincoln和UNMC）的协作追求中，将氧化还原生物学中的基本问题联系起来，这些问题影响了许多疾病的发病机理，包括某些癌症，关节炎和心血管疾病和自然现象的进展，例如某些癌症。拟议中心的目标是（i）通过创建一个基础设施来提高国家的生物医学研究能力，该基础设施将在两家机构的氧化还原生物学中策略性地联系起来，并（ii）指导初级教师干部以在NIH获得独立的资金成功。 通过促进机构的科学家之间的合作，并招募五名在Redox生物学领域具有研究兴趣的其他教职员工之间，通过促进科学家之间的合作，通过促进核心设施来为初级调查人员提供丰富而严格的指导环境，以实现这些目标，以确保维持国家可见的和国际公认的中心。该中心组织的一个关键设计功能是由一名具有类似研究兴趣的研究人员和NIH的成功融资记录对五位发展中的教职员工进行指导。当这些项目领导者过渡到资金独立性时，他们的项目将由新招聘的教职员工领导的项目取代。具有远见，科学专业知识和行政经验的董事，提供有效的领导才能将主要负责转向该中心。她将由指导理事会成员的咨询，包括内布拉斯加州机构的五名成熟科学家，并由由八名杰出科学家组成的外部咨询委员会（EAC）的指导，其中五位是国家科学院的成员，他们都同意以这一身份服务。 由中心创建所产生的协同环境将丰富该州的研究文化，将使其生物医学科学家社区充满活力，并将提高关键核心设施的质量和产品。