MT COBRE: HOUSEHOLD ENVIRONMENTAL RISK REDUCTION IN RURAL CHILDREN

MT COBRE：减少农村儿童的家庭环境风险

• 批准号: 7171052
• 负责人: Wade Garrison Hill
• 金额: $ 15.11万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171052
• 关键词: clinical research; environmental health; health science research potential; health science research support

DESCRIPTION (provided by applicant): The CEHS was established in 2000 with the goal of developing a nationally competitive research program to study the mechanism of human disease and environmental impacts on human disease. In order to achieve this goal three focus areas of research were selected in order to facilitate the development of a critical mass of investigators in each area and on the basis of national need and expertise within the existing faculty. These focus areas are respiratory/immunotoxicology, neurotoxicology, and genetic and cardiovascular toxicology. With the aid of startup support five talented new faculty were hired and a sixth is being recruited. State-of-the-art core facilities were established and a strong mentoring program was put into place. This COBRE application is an ideal fit to develop the new faculty, hire additional faculty to further enhance the existing faculty and to enhance the support network and the infrastructure to develop the CEHS to a nationally competitive center. The specific aims of this application are: Aim 1 Promote the development of six talented faculty through the support of individual sub-projects Aim 2 Enhance the critical mass of competitive CEHS investigators at the UM through strategic recruitment of four new faculty. Aim 3 Establish a support network for CEHS investigators that promotes infrastructure development, collaborative interaction and facilitate mentoring. Aim 4 Enhance the infrastructure for CEHS research through the acquisition of critically needed instrumentation for a shared ICPMS and Flow Cytometer; and improve facilities, i.e., clean room for ICPMS, tissue culture, small animal surgery and a bioinformatics and computational core facility. We propose that with the achievement of these specific aims that all of the investigators supported by this COBRE grant will move into R01 funding and that the an overall research environment will have been created so that the CEHS investigators will be able to obtain a NIEHS center grant, a Ph.D. training grant from the NIEHS and program project grant support.

描述（由申请人提供）：CEHS 成立于 2000 年，其目标是开发一个具有全国竞争力的研究项目，以研究人类疾病的机制以及环境对人类疾病的影响。为了实现这一目标，选择了三个重点研究领域，以促进每个领域的关键研究人员的发展，并根据国家需求和现有教师的专业知识。这些重点领域是呼吸/免疫毒理学、神经毒理学以及遗传和心血管毒理学。在启动支持的帮助下，聘用了五名才华横溢的新教师，并且正在招募第六名教师。建立了最先进的核心设施，并实施了强有力的指导计划。该 COBRE 应用程序非常适合培养新教师、雇用更多教师以进一步增强现有教师队伍以及增强支持网络和基础设施，从而将 CEHS 发展成为具有全国竞争力的中心。 该应用程序的具体目标是： 目标1 通过单个子项目的支持，促进六名优秀教师的发展 目标 2 通过战略性招聘四名新教师，增强 UM 竞争性 CEHS 研究人员的临界质量。 目标 3 为 CEHS 研究人员建立一个支持网络，促进基础设施发展、协作互动并促进指导。 目标 4 通过购买共享 ICPMS 和流式细胞仪急需的仪器来增强 CEHS 研究的基础设施；改善设施，即ICPMS洁净室、组织培养、小动物手术以及生物信息学和计算核心设施。 我们建议，随着这些具体目标的实现，COBRE 资助支持的所有研究人员都将进入 R01 资助，并且将创建一个整体研究环境，以便 CEHS 研究人员能够获得 NIEHS 中心资助，博士。来自 NIEHS 的培训补助金和计划项目补助金支持。