COBRE: UND: CARBONYL DETOXIFICATION IN CNS

COBRE：UND：中枢神经系统中的羰基解毒

• 批准号: 7171126
• 负责人: MATTHEW J PICKLO
• 金额: $ 18.82万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171126
• 关键词: clinical research; neural degeneration; neurosciences; pathologic process; clinical research; neural degeneration; neurosciences; pathologic process

DESCRIPTION (provided by applicant): This proposal is to establish a Center of Biomedical Research Excellence (COBRE) on the Pathophysiology of neurodegenerative diseases at the University of North Dakota. The overall objective of this Center is to characterize the cellular mechanisms that contribute to neuronal degeneration. The proposed Center will consist of five projects involving 6 junior faculty members, each of which examines a unique aspect of the neurodegenerative process. These five projects, together with the proposed core facilities, faculty recruitments and administrative core will greatly assist us in meeting our long term goal: To develop a highly interactive and collaborative research group focused on understanding the etiology of neurodegeneration and developing therapeutic approaches to prevent or halt neuropathology. The Specific Aims of this COBRE are: 1.) To develop successful independent research projects for the COBRE project directors that will enable them to obtain extramural R01 research grants. 2.) To enhance research infrastructure at the University of North Dakota School of Medicine & Health Sciences (UNDSMHS) through the development of core facilities to support all investigators. 3.) To expand biomedical faculty research in the area of neuroscience through the recruitment of an established senior level neuroscientist and four junior faculty members to UNDSMHS whose research is in the theme of our COBRE. These new faculty recruits will establish a critical mass of researchers at UNDSMHS whose areas of research expertise are in complimentary areas of neuroscience. 4.) To establish a nationally and internationally recognized Center of Neuroscience Research Excellence at the University of North Dakota. The successful completion of COBRE Specific Aims will establish a reputation at UNDSMHS as a Center of Neuroscience Research Excellence that will attract faculty, postdoctoral fellows, and graduate students interested in neuroscience research. Our Center will then be highly competitive for obtaining training grants, program project grants and center grants that will allow for the continuation of the Center of Neuroscience Research Excellence beyond the COBRE award.

描述（由申请人提供）：该建议是建立北达科他大学神经退行性疾病病理生理学的生物医学研究中心（Cobre）。该中心的总体目的是表征有助于神经元变性的细胞机制。拟议的中心将由五个涉及6名初级教职员工的项目组成，每个项目都检查了神经退行性过程的独特方面。这五个项目以及拟议的核心设施，教师招聘和行政核心将极大地帮助我们实现我们的长期目标：建立一个高度互动和协作的研究小组，专注于了解神经变性的病因以及开发预防或阻止神经病理学的治疗方法。该毛绒的具体目的是：1。）为Cobre项目主管开发成功的独立研究项目，以使他们能够获得壁外R01研究补助金。 2.）通过开发核心设施来支持所有研究人员，以增强北达科他大学医学与健康科学学院（UNDSMHS）的研究基础设施。 3.）通过招募已建立的高级神经科学家和四名初级教师的生物医学教师研究，将其研究为我们的cobre主题。这些新的教师新兵将在UNDSMHS建立批判的研究人员，其研究专业领域是在神经科学领域的免费领域。 4.）在北达科他大学建立一个国家和国际公认的神经科学研究中心。 Cobre特定目标的成功完成将在UNDSMHS享有声誉，成为卓越神经科学研究中心，该中心将吸引教师，博士后研究员和对神经科学研究感兴趣的研究生。然后，我们的中心将在获得培训补助金，计划项目补助金和中心赠款方面具有很高的竞争力，这将使神经科学研究中心的卓越中心超越鞋垫奖。