MOLECULAR STUDIES USING AN AUTOMATED DNA SEQUENCER

使用自动 DNA 测序仪进行分子研究

• 批准号: 6876312
• 负责人: Minnie McMillan
• 金额: $ 21.2万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6876312
• 关键词: biomedical equipment purchase; biotechnology; high throughput technology; molecular biology; molecular genetics; nucleic acid sequence

DESCRIPTION (provided by applicant): The proposal requests funds to purchase an AB 3730XL DNA sequencer, to replace two aging AB 377 instruments. It would be housed in the USC/Norris Comprehensive Cancer Center Microchemistry Core Laboratory, which offers a DNA sequencing service to peer-reviewed investigators. Acquisition of this new instrument will ensure that researchers at the University of Southern California have ready access to state-of-the-art DNA sequencing. This is essential in their endeavors to study fundamental mechanisms such as gene regulation, signal transduction, and DNA repair in normal and neoplastic cells. In addition, it will also advance the understanding of the genetic basis of disease, the design of vaccines and the development of therapies in the treatment of cancer, graft rejection and autoimmunity.

描述（申请人提供）：该提案要求资金购买AB 3730xl DNA Sequencer，以替换两种老化的AB 377仪器。它将安置在USC/Norris综合癌症中心微化学核心实验室中，该实验室为同行评审的研究人员提供DNA测序服务。收购这项新工具将确保南加州大学的研究人员可以随时获得最先进的DNA测序。这对于研究正常和肿瘤细胞中基因调节，信号转导和DNA修复等基本机制至关重要。此外，它还将提高人们对疾病遗传基础，疫苗设计以及癌症治疗，移植排斥和自身免疫性的疗法的理解。