Diurnal Preference in Amish Families

阿米什家庭的昼夜偏好

• 批准号: 6944718
• 负责人: WEN-CHI HSUEH
• 金额: $ 14.85万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6944718
• 关键词: Mennonite; actigraphy; age difference; behavioral /social science research tag; behavioral genetics; biological clocks; body physical characteristic; circadian rhythms; clinical research; computed axial tomography; data collection methodology /evaluation; gender difference; gene environment interaction; gene expression; genetic polymorphism; human population study; human subject; insulin sensitivity /resistance; linkage mapping; phenotype; photon absorptiometry; preference; questionnaires; sleep; statistics /biometry; urinalysis

DESCRIPTION (provided by applicant): In this Career Development Award application, I will lay the foundation for epidemiological and genetic studies of circadian rhythm in human populations. This proposed study is designed to obtain valuable information for the planning of more comprehensive studies of circadian rhythm in the near future. Prior studies have suggested that the diurnal preference is heritable and changes in circadian clock are associated with aging. We hypothesize that diurnal preference, a component of circadian rhythm, is variable and heritable in the Old Order Amish (OOA) and it is associated with aging. The primary objectives of this research proposal are three-fold: (1) to investigate the association between human diurnal preference and aging-related phenotypes at a population level; (2) to characterize genetic epidemiology of diurnal preference, including a genome-wide linkage analysis; and 3) to evaluate the usefulness of actigraphy in the studies of circadian rhythm. We plan to collect information on diurnal preference using the Horne-Ostberg questionnaire from 1,000 participants in the Amish Family Cardiovascular Intervention Study (AFCVIS) and 300 Amish participants of the "Longevity Genes in Founder Populations Study" (LGFPS), two newly initiated studies designed for studying genetic determinants of cardiovascular diseases, osteoporosis, and longevity. In addition, we will obtain 7-day actigraph and sleep log records from 200 volunteers in the LGFP study. Extensive information on aging-related phenotypes and a 5-cM genome scan are already available in these people. Our goal is to efficiently expand our data collection to study diurnal preference, and eventually, circadian rhythm. This proposed family study in a genetically homogeneous founder population with an "old-fashioned" life style provides a unique opportunity to study diurnal preference in a large and free-living human population.

描述（由申请人提供）：在本职业发展奖申请中，我将为人口中昼夜节律的流行病学和遗传研究奠定基础。 这项拟议的研究旨在获取有价值的信息，以计划在不久的将来对昼夜节律进行更全面的研究。 先前的研究表明，昼夜偏好是可遗传的，昼夜节律的变化与衰老有关。 我们假设昼夜节奏的昼夜偏好在旧顺序Amish（OOA）上是可变且可遗传的，并且与衰老有关。 这项研究提案的主要目标是三重：（1）研究人群水平上人类昼夜偏好与与衰老相关的表型之间的关联； （2）表征昼夜偏爱的遗传流行病学，包括全基因组的连锁分析； 3）评估昼夜节律研究中行为的有用性。 我们计划使用Amish家庭心血管干预研究（AFCVIS）中的1,000名参与者的Horne-Ostberg问卷收集有关昼夜偏好的信息，以及300名Amish参与者的“创始人人群研究中的长寿基因研究”（LGFPS）（LGFPS）（LGFPS），两项新启动的研究，用于研究遗传性疾病，并研究了遗传性疾病。 此外，在LGFP研究中，我们还将从200名志愿者那里获得7天的Actigraph和睡眠日志记录。 这些人已经获得了有关与衰老相关的表型和5厘米基因组扫描的广泛信息。 我们的目标是有效地扩展我们的数据收集，以研究昼夜偏好，最终是昼夜节律。 这项在具有“老式”生活方式的遗传均质创始人人群中提出的家庭研究为研究庞大而自由生活的人口中的昼夜偏好提供了独特的机会。