Retinal drive of spontaneous system activity

自发系统活动的视网膜驱动

基本信息

批准号：
7389998
负责人：
MATTHEW T COLONNESE
金额：
$ 0.7万
依托单位：
INSERM UNIT 29
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-03-15 至 2009-03-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7389998
关键词：
Action Potentials Adult Anesthesia procedures Arousal Behavior Biological Pacemakers Birth Brain Chemosensitization Chronic Development Electric Stimulation Electrodes France Frequencies Generations Implant Laboratories Lateral Geniculate Body Localized Mammals Maps Methods Modeling Muscle Neocortex Neonatal Neurons Neuropil Newborn Animals Pattern Perinatal Physiology Range Rattus Retina Retinal Retinal Ganglion Cells Role Sensory Silicon Dioxide Sleep Somatosensory Cortex Structure Synapses Synaptic plasticity System Testing Thalamic Nuclei Thalamic structure Time Travel Vision Visual Visual Cortex Visual system structure Week Whole-Cell Recordings Work area striata awake day driving force experience extracellular ganglion cell in vivo interest langanite neonate research study retinotopic size superior colliculus Corpora quadrigemina

项目摘要

The patterns of activity in the brains of neonates, though it is critical for the normal development of synaptic connectivity, is largely unknown. Recent work has shown that in the cortex of neonatal rats, nearly all neuronal activity consists of bursts of synchronous oscillatory activity similar to spindle waves observed in adults during sleep. In the somatosensory cortex these bursts are correlated with spontaneous muscle jerks and sensory input. How precisely such correlation comes about will be important to understand how different regions coordinate activity in the time before normal sensory input develops. The visual system is an excellent model in which to study this question. Much of the organization of the visual system occurs before vision, driven by spontaneous bursts of activity in retinal ganglion cells. Through a combination of paired recordings, pharmacological manipulation of the retina, and electrical stimulation, the experiments in this proposal will discern if retinal activity patterns activity in the major visual targets, or if it acts to trigger endogenous oscillators centrally. This information will aid in the development of accurate models of activity dependent development.

新生儿大脑的活动模式，尽管它对于突触的正常发育至关重要连接性，很大程度上是未知的。最近的研究表明，在新生大鼠的皮质中，几乎所有神经元活动由同步振荡活动的爆发组成，类似于在中观察到的纺锤波成人在睡眠时。在体感皮层中，这些爆发与自发性肌肉抽搐相关和感觉输入。这种相关性是如何精确产生的对于理解如何产生非常重要在正常感觉输入出现之前，不同区域协调活动。视觉系统是一个研究这个问题的优秀模型。视觉系统的大部分组织发生在视觉之前，由视网膜神经节细胞自发爆发的活动驱动。通过组合配对录音、视网膜药理操作和电刺激等实验该提案将辨别视网膜活动是否模式化主要视觉目标的活动，或者它是否起到触发作用内源性振荡器集中。这些信息将有助于开发准确的活动模型依赖发展。