Novel CSF biomarker to predict impaired cognition in HIV

新型脑脊液生物标志物可预测艾滋病毒认知受损

• 批准号: 7111609
• 负责人: Dana Giulian
• 金额: $ 103.25万
• 依托单位: INFLAME THERAPEUTICS, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7111609
• 关键词: AIDS /HIV neuropathy; AIDS dementia complex; biomarker; cerebrospinal fluid; clinical research; cognition; cognition disorders; diagnosis design /evaluation; diagnostic tests; early diagnosis; health related legal; human subject; laboratory rat; mental disorder diagnosis; nervous system disorder diagnosis; neural information processing; neuropathology; neuropsychological tests; neurotoxins; patient oriented research; synapses; technology /technique development; tissue /cell culture

DESCRIPTION (provided by applicant): The focus of this project is to explore the relationship between inflammatory cells and cognitive dysfunction in populations with HIV-1 infection. Extensive work has found that a biomarker is detected in lumbar cerebrospinal fluid of HIV(+) subjects with impaired cognition. Presently there are no suitable clinical tests to identify early neuro-inflammatory injury to neurons in such disorders as HIV-1 dementia. The ability to identify and treat HIV(+) populations before the onset of irreversible brain damage is highly desirable and forms the basis for this STTR proposal.

描述（由申请人提供）：该项目的重点是探索HIV-1感染人群中炎症细胞与认知功能障碍之间的关系。广泛的工作发现，在认知受损的艾滋病毒（+）受试者的腰椎脑脊液中检测到生物标志物。目前，没有适当的临床测试可以鉴定出HIV-1痴呆等疾病中神经元的早期神经炎症性损伤。在不可逆转的脑损伤开始之前，识别和治疗艾滋病毒（+）种群的能力是非常需要的，并构成了该STTR建议的基础。