High Flux Blood Oxygenators

高通量血液氧合器

• 批准号: 7158351
• 负责人: LAURA CARMICHAEL
• 金额: $ 16.96万
• 依托单位: COMPACT MEMBRANE SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2008-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7158351
• 关键词: artificial membranes; bioengineering /biomedical engineering; biomaterial development /preparation; biotechnology; blood oxygenator; extracorporeal circulation; fluid flow; respiratory gas

DESCRIPTION (provided by applicant): Historically blood oxygenator technology either for short-term by-pass surgery or recently developed long-term strategies has been mass transfer limited by liquid side mass transfer fluid dynamics. Recent active mixing designs have led to systems which remove liquid side fluid limitations and have oxygen and carbon dioxide transport limited by membrane transport. Compact Membrane Systems (CMS) has identified a new family of microporous hollow fiber membranes with superior mass transfer and wet out resistance compared to commercial microporous polypropylene hollow fiber. If these new membranes are demonstrated to have superior mass transfer and wet out resistance they will further reduce the size of active mixing blood oxygenators. In Phase I, we will fabricate these microporous hollow fibers and demonstrate their superiority to commercial microporous polypropylene hollow fibers in mass transfer of blood gases (e.g. Oxygen and/or carbon dioxide) and wet out resistance. Parallel work at University of Pittsburgh will demonstrate bio-compatibility, wet-out resistance, and superior mass transfer. CMS has key industrial relations in place that if Phase I and II are successful that commercialization can be accelerated. NIH05.14? Project Narrative Active mixing membrane systems have recently been developed to support long-term blood oxygenation protocols. In these active mixing membrane systems, the overall system performance is limited by the mass transfer of the membrane itself. This program will introduce a new family of membranes with superior mass transfer compared to existing commercial microporous polypropylene hollow fibers and therefore better active mixing performance. The new family of membranes is also expected to have superior blood wet out resistance. Compact Membrane Systems, Inc.

描述（由申请人提供）：历史上用于短期旁通手术或最近开发的长期策略的血液氧化剂技术受到液体侧传质流体动力学的限制。最近的主动混合设计导致了消除液体侧流体限制的系统，并通过膜运输限制了氧气和二氧化碳运输。与商业的微孔聚丙烯空心纤维相比，紧凑型膜系统（CMS）已确定了具有优越的传质和湿球的新型微孔空心纤维膜家族。如果证明这些新膜具有优越的传质和湿能，则将进一步降低活性混合血氧的大小。在第一阶段，我们将制造这些微孔空心纤维，并证明它们优于商业微孔聚丙烯空心纤维在血液（例如氧气和/或二氧化碳）中的大传递中，并湿出耐药性。匹兹堡大学的平行工作将证明生物兼容，湿能力和出色的传质。 CMS拥有关键的劳资关系，如果第一阶段和第二阶段成功，可以加速商业化。 NIH05.14？最近已经开发了项目叙事主动混合膜系统，以支持长期的血液氧合方案。在这些活跃的混合膜系统中，整体系统性能受到膜本身的传质的限制。与现有的商业微孔聚丙烯空心纤维相比，该程序将引入一个新的膜家族，具有较高的传质，因此可以更好地进行活跃的混合性能。新的膜家族也有望具有较高的血液阻力。紧凑型膜系统公司