A Wireless, Multi-Channel Telemetric Biosensor for Research in Animal Models

用于动物模型研究的无线多通道遥测生物传感器

• 批准号: 7155091
• 负责人: KINGMAN PERKINS STROHL
• 金额: $ 13.04万
• 依托单位: NANOCOMPONENT, LTD
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2008-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7155091
• 关键词: conditioning; dissection; genetics; heart rate; model; performance; restraint; sleep; temperature; university

DESCRIPTION (provided by applicant): Modern medical science is dependant upon animal models, for both basic research and evaluation of new interventions and drugs. Physiological investigation of various biological issues commonly requires the collection of biophysical and biochemical parameters in animal studies. Typically initial experiments are carried out in small mammals, such as a mouse or rat, and new paradigms involve the comparisons of strains and sub-strains of mice and rats to identify genetic sources of variability. Available techniques to transmit the sensor outputs to the external environment involve wire connections and restraint tethering, which limit animal movement and recording conditions, or involve fixed integrated wireless systems of 1-3 channels, applicable to only 1 animal at a time. Studies of physiologic variations over time are needed to assess disease progress (or regression) or drug effects, and such studies are preferably performed in the unrestrained and unanaesthetized rodent. The current limitation of technology is the interface between chip technology and multiple and modifiable sensors. Connectors at present cannot accommodate the tailored placements of recording for sleep, heart rate, temperature, etc, and thus limit utility, increase animal use, and overspecialize the technology to unique sites. Nanocomponent, Ltd., in partnership with Case Western Reserve University, proposes to develop a wireless, multi-channel telemetric biosensor for research in animal models amendable to genetic dissection. This microsystem is an interface between the parameter sensors and the external environment. The multi-channels means a minimum of 4 input channels and can extend to 8 or more channels. Specifically, multi-channel wireless telemetric microsystems for biopotentials, temperature, and pressure will be developed. Other potential biochemical parameters will be considered. Integration of these biophysical and biochemical parameters into a multi-channel wireless telemetric microsystem is the ultimate goal of this research. The proposed research will facilitate animal studies that may lead to a better understanding of sleep disorders and potentially new interventions.

描述（由申请人提供）：现代医学取决于动物模型，用于基础研究和新干预措施和药物的评估。对各种生物学问题的生理研究通常需要在动物研究中收集生物物理和生化参数。通常，初始实验是在小型哺乳动物（例如小鼠或大鼠）中进行的，而新的范式涉及菌株和小鼠和大鼠的菌株和亚菌属的比较，以鉴定可变性的遗传源。将传感器输出传输到外部环境的可用技术涉及电线连接和约束束缚，从而限制动物运动和记录条件，或涉及1-3个通道的固定集成的无线系统，一次仅适用于1个动物。随着时间的流逝，需要对生理变异进行研究，以评估疾病的进步（或消退）或药物作用，并且优选在不受限制的和单障碍的啮齿动物中进行此类研究。技术的当前局限性是芯片技术与多个可修改传感器之间的接口。目前，连接器无法容纳用于睡眠，心率，温度等记录的量身定制的放置，从而限制了效用，增加动物使用并将技术过度专业化到独特的地点。 Nanocomponent，Ltd。与Case Western Reserve University合作，建议开发一种无线的多通道远程遥测生物传感器，用于在动物模型中进行的研究，可以通过遗传解剖来修正。该微系统是参数传感器和外部环境之间的接口。多通道意味着至少4个输入通道，并且可以扩展到8个或更多通道。具体而言，将开发用于生物电位，温度和压力的多通道无线遥测微系统。将考虑其他潜在的生化参数。将这些生物物理和生化参数集成到多通道无线遥测微系统中是这项研究的最终目标。拟议的研究将促进动物研究，这可能会导致对睡眠障碍和潜在的新干预措施更好地了解。