Epidemiology of human metapneumovirus(hMPV) infection

人类偏肺病毒（hMPV）感染的流行病学

• 批准号: 6965811
• 负责人: Marietta Vazquez
• 金额: $ 13.31万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6965811
• 关键词: Pneumovirus; adolescence (12-20); asthma; child (0-11); children; clinical research; comorbidity; disease /disorder proneness /risk; genetic screening; genotype; human subject; interview; longitudinal human study; medical complication; pathologic process; polymerase chain reaction; public health; racial /ethnic difference; respiratory disorder diagnosis; respiratory disorder epidemiology; respiratory infections; vaccine evaluation; viral pneumonia; viral vaccines

DESCRIPTION (provided by applicant): Dr. Vazquez's long-term goals are: 1) to become an independent physician-scientist who conducts high quality patient-oriented research that answers important clinical and epidemiologic questions 2) to become a role model and a mentor for younger physicians and 3) to become an expert in case-control and prospective cohort studies that integrate the tools of molecular biology in studies of viral infections in children. She plans to become an expert in these research methodologies using the studies as model systems that can then be successfully applied to other studies of pediatric infections. The proposed program of didactic training and intensive involvement in research, to which she will devote 80% of her time, will allow her to accomplish these goals. She has trained in Pediatric Infectious Diseases and has had successful experiences conducting patient-oriented research projects. She will spend up to 30% of her time in the first 3 years of the project period gaining advanced training in research methodology-in particular, advanced training in multivariable biostatistical methods and molecular biologic techniques and their application to her studies of pediatric infections, through graduate-level courses. With the guidance of her mentors, Dr. Shapiro & Dr. Kahn, she will conduct 2 studies: 1) A prospective longitudinal cohort study of human metapneumovirus (hMPV) infection in children. This study aims: a) to describe the clinical epidemiology of hMPV infection in children (including its association with wheezing and the development of asthma later in life); b) to identify risk factors for infection (eg, prematurity, exposure to cigarette smoke, race); and c) to define the molecular epidemiology of hMPV infection (e.g., the relationships among genotypes, associations between genotype and severity of illness, and differences in the strains from one epidemic year to the next) and 2) A matched case-control study of the long-term effectiveness of varicella vaccine in children that also aims to assess the effects of time since vaccination and of age at the time of vaccination on the effectiveness of the vaccine. Both studies target key public health issues and are likely to influence public health policy. The experience gained through the combination of didactic training and intensive research will provide the foundation for her to develop new studies of public health importance for which she will apply for independent R-01 funding by the end of the period of the proposed program.

描述（由申请人提供）： Vazquez 博士的长期目标是：1) 成为一名独立的医师科学家，开展高质量的以患者为中心的研究，回答重要的临床和流行病学问题 2) 成为年轻医生的榜样和导师，3)成为病例对照和前瞻性队列研究的专家，将分子生物学工具整合到儿童病毒感染的研究中。她计划成为这些研究方法的专家，将这些研究作为模型系统，然后可以成功应用于儿科感染的其他研究。拟议的教学培训和深入参与研究计划将使她能够实现这些目标，她将投入 80% 的时间。她接受过儿科传染病方面的培训，并拥有开展以患者为导向的研究项目的成功经验。在项目期间的前 3 年，她将花费多达 30% 的时间获得研究方法方面的高级培训，特别是多变量生物统计方法和分子生物学技术及其在儿科感染研究中的应用的高级培训，通过研究生水平的课程。在导师 Shapiro 博士和 Kahn 博士的指导下，她将进行 2 项研究：1）儿童人类偏肺病毒 (hMPV) 感染的前瞻性纵向队列研究。本研究的目的： a) 描述儿童 hMPV 感染的临床流行病学（包括其与喘息和日后哮喘发展的关系）； b) 确定感染的危险因素（例如，早产、接触香烟烟雾、种族）； c) 定义 hMPV 感染的分子流行病学（例如，基因型之间的关系、基因型与疾病严重程度之间的关联以及从一个流行年到下一个流行年毒株的差异）和 2) 一项匹配的病例对照研究水痘疫苗对儿童的长期有效性，还旨在评估接种疫苗后的时间和接种疫苗时的年龄对疫苗有效性的影响。 这两项研究都针对关键的公共卫生问题，并可能影响公共卫生政策。通过教学培训和深入研究相结合获得的经验将为她开展具有公共卫生重要性的新研究奠定基础，她将在拟议项目结束时申请独立的 R-01 资金。