Trial of Behavioral Changes in Home Exposure Control

家庭暴露控制行为改变试验

• 批准号: 6960267
• 负责人: Peyton A Eggleston
• 金额: $ 14.79万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-07 至 2008-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6960267
• 关键词: air pollution; air pollution control; airborne allergen; asthma; child (0-11); clinical trials; cockroach; cognitive behavior therapy; environmental exposure; health behavior; health care service utilization; health education; human morbidity; human subject; human therapy evaluation; outcomes research; patient oriented research; quality of life; respiratory disease /disorder therapy; smoke inhalation; smoking; smoking cessation; spirometry; therapy compliance; urban area

In preliminary analysis of the home based environmental intervention trial currently being conducted by the Center, we have found that indoor airborne PM was reduced by 31-42% and that cockroach allergen was reduced 45%. Building on this success we will test an intervention that is heavily behavioral, intended to reduce particulate sources and increase use of room air filters. This CPBR randomized controlled intervention trial is designed to compare the effectiveness of a targeted home-based particulate and allergen control behavioral education program to a traditional office-based education in decreasing home allergen and particulate levels and asthma symptoms in asthmatic children and who are exposed to ETS on a regular basis in their home. We will recruit 120 children aged 6-12 years with currently active asthma who report regular ETS exposure in the home. Each child and their family will undergo a baseline evaluation that will include questionnaires, allergy skin tests, spirometry, and a home visit to evaluate particulate and allergen control behaviors and settled dust allergen measurements. After receiving traditional particulate and allergen control education in a clinic setting, participants will be randomized to a Usual Care Group or an Intervention Group. The Intervention Group will receive a home-based behavioral education and coaching program provided by trained environmental health coaches. The intervention will be tailored to the individual particulate and allergen exposure profile of each child. Particulate control interventions will target the child's particulate exposure risk profile based on the home evaluation data. Allergen control interventions will address environmental exposure to dust mites, cockroaches, cats and dogs. Telephone interviews will evaluate symptoms and behaviors at 3, 6, 9 and 12 months post randomization. The primary outcome will be change in particulate levels and target environmental allergens in the home and change in asthma-related quality of life. Secondary outcomes include adherence with environmental control recommendations, rhinoconjunctivitis-related quality of life, FEV1, changes in other environmental allergens and particulates, self-efficacy for environmental allergy, and particulate control and healthcare utilization.

中心目前正在进行的家庭环境干预试验的初步分析发现，室内空气中的PM减少了31-42%，蟑螂过敏原减少了45%。在此成功的基础上，我们将测试一种行为干预措施，旨在减少颗粒物来源并增加室内空气过滤器的使用。这项 CPBR 随机对照干预试验旨在比较 有针对性的家庭颗粒物和过敏原控制行为教育计划与传统办公室教育相比，在降低哮喘儿童和定期在家中接触 ETS 的家庭过敏原和颗粒物水平以及哮喘症状方面的有效性。 我们将招募 120 名目前患有哮喘的 6-12 岁儿童，他们报告在家中经常接触 ETS。每个孩子及其家人都将接受基线评估，包括问卷调查、过敏皮肤测试、肺活量测定以及家访，以评估颗粒物和过敏原控制行为以及沉降的灰尘过敏原测量。在诊所接受传统的颗粒物和过敏原控制教育后，参与者将被随机分配到常规护理组或干预组。干预小组将获得以家庭为基础的 由经过培训的环境健康教练提供行为教育和辅导计划。干预措施将根据每个儿童的个体颗粒物和过敏原暴露情况进行定制。颗粒物控制干预措施将根据家庭评估数据针对儿童的颗粒物暴露风险状况。过敏原控制干预措施将解决尘螨、蟑螂、猫和狗的环境暴露问题。电话面试将评估 随机分组后 3、6、9 和 12 个月的症状和行为。主要结果将是家庭中颗粒物水平和目标环境过敏原的变化以及哮喘相关生活质量的变化。 次要结果包括遵守环境控制建议、鼻结膜炎相关的生活质量、FEV1、其他环境过敏原和颗粒物的变化、环境过敏的自我效能以及颗粒物控制和医疗保健利用。