University of Maryland Biomarker Reference Laboratory

马里兰大学生物标志物参考实验室

• 批准号: 7034654
• 负责人: STANFORD A. STASS
• 金额: $ 41.78万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-21 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7034654
• 关键词: Barretts esophagus; biomarker; clinical research; cooperative study; early diagnosis; esophagus neoplasm; flow cytometry; human subject; immunocytochemistry; longitudinal human study; methylation; polymerase chain reaction

DESCRIPTION (provided by applicant): The Early Detection Research Network (EDRN) of the NCI has directed the establishment of several Biomarker Reference Laboratories to move biomarkers developed within the EDRN into the clinic. The University of Maryland Biomarker Reference Laboratory (UMB-BRL) will fulfill this mission. The UMB-BRL will enable biomarker validation by providing a wide range of core facilities and shared services, specialized equipment, and quality control systems, including CLIA certification and full clinical laboratories as well as molecular genetic assays within its versatile armamentarium. Resources provided will include histopathology, immunohistochemistry, clinical and research chemistry, molecular diagnostics, genomics, proteomics, flow cytometry research, biostatistics, an industrial ultra sensitive multiphoton detection technology laboratory, a broad tissue bank, and other resources. An expert team of leaders at UMB and industrial sites has been assembled to provide access to these core facilities and shared services, led by the PI, Dr. Stephen Meltzer, who has five years of experience participating in the EDRN as the PI of a Biomarkers Development Laboratory (BDL). The UMB-BRL will leverage both the EDRN experience of the PI and the considerable expertise of the leadership team to provide standardized procedures, high-throughput robust assays, generalizability, and clinical translation into CLIA-certified laboratories, in which the Co-PI, Dr. Sanford Stass, has extensive experience and expertise. Numerous extant collaboration within and outside UMB will guarantee maximum responsiveness to the demands of the EDRN. Lines of authority and an organizational structure have been clearly established at the UMB-BRL to ensure timely performance, effective communication, and rapid translation of biomarkers from the discovery phase into the clinical arena.

描述（由申请人提供）：NCI的早期检测研究网络（EDRN）指示建立几个生物标志物参考实验室，以将EDRN内发展的生物标志物转移到诊所中。马里兰大学生物标志物参考实验室（UMB-BRL）将履行这一任务。 UMB-BRL将通过提供广泛的核心设施和共享服务，专业设备和质量控制系统，包括CLIA认证和完整的临床实验室，以及其多功能性手臂的分子遗传分析，从而实现生物标志物验证。提供的资源将包括组织病理学，免疫组织化学，临床和研究化学，分子诊断，基因组学，蛋白质组学，流式细胞仪研究，生物统计学，一种工业超敏感的多人检测技术实验室，广泛的组织库和其他资源。由PI，由PI，Stephen Meltzer博士领导的UMB和工业网站领导者的专家团队已组装，以提供这些核心设施和共享服务的访问权限，他拥有五年的EDRN经验，作为生物标志物的PI。开发实验室（BDL）。 UMB-BRL将利用PI的EDRN体验和领导团队的大量专业知识来提供标准化的程序，高通量的强大测定法，可推广性和临床转换为CLIA认证的实验室，其中Co-Pi，Co-Pi，Co-Pi，copi，co-pi，copi，co-pi， Sanford Stass博士拥有丰富的经验和专业知识。 UMB内部和外部的许多现有合作将确保对EDRN需求的最大响应能力。在UMB-BRL上已经明确建立了权威和组织结构，以确保及时的性能，有效的沟通以及从发现阶段转化为临床领域的生物标志物的快速翻译。