Training in Pharmacoinformatics

药物信息学培训

• 批准号: 7121516
• 负责人: GEORGE M. STANCEL
• 金额: $ 23.62万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7121516
• 关键词: Chordata; NIH Roadmap Initiative tag; clinical research; computational biology; cooperative study; drug design /synthesis /production; drug discovery /isolation; education evaluation /planning; functional /structural genomics; health science research potential; informatics; interdisciplinary collaboration; pharmacology; postdoctoral investigator; predoctoral investigator; proteomics; science education; training

Support is requested for 9 predoctoral and 6 postdoctoral positions to establish a training program in the interdisciplinary area of Pharmacoinformatics. This program is proposed because current approaches to the discovery of new drugs have not fully capitalized on advances in bioinformatics, genomics, computing and other fields, and consequently, the rate of drug discovery has lagged behind breakthroughs in these areas. The pipeline of new drugs under development has not increased in recent years, and a very small number of new drags are thus responsible for bearing the enormous costs of an increasingly expensive process that evolved prior to development of massive amounts of new information and the ability to integrate it into usable and accessible systems. We propose a comprehensive, integrated program to train the next generation of scientists to: (1) use informatics approaches to identify biomolecules that are candidates for drug targeting, (2) use structural genomics, chemoinformatics, and structure-based design to develop families of chemicals to target selected biomolecules and structures, and (3) use ADMET (absorption, distribution, metabolism, elimination, and toxicity) profiling and computational predictions of efficacy to select viable drag candidates prior to biological testing. Training will emphasize in silico approaches to achieve these goals. Inter-institutional training will be conducted by sixty-three training faculty from the six institutions of the Gulf Coast Consortia (Baylor College of Medicine, M. D. Anderson Cancer Center, Rice University, the University of Houston, The University of Texas Health Science Center at Houston, and The University of Texas Medical Branch at Galveston) in the Houston -Galveston area and will utilize research training with co-mentors, didactic courses, seminars, retreats, and career development activities. Predoctoral trainees will matriculate and receive first year support at their home institutions, and stipends will be awarded on a competitive basis for years 2-4 of graduate training. The home institution will award the Ph.D. Postdoctoral trainees will receive support for two years maximum. The proposed program is designed to train future leaders in drag discovery research.

请求支持 9 个博士前职位和 6 个博士后职位，以建立药物信息学跨学科领域的培训计划。提出这一计划的原因是，目前新药发现的方法尚未充分利用生物信息学、基因组学、计算机等领域的进步，因此药物发现的速度落后于这些领域的突破。近年来，正在开发的新药管道并没有增加，因此，极少数新药要承担日益昂贵的工艺的巨大成本，该工艺是在开发大量新信息和开发能力之前发展起来的。将其集成到可用且可访问的系统中。我们提出了一个全面、综合的培训计划 下一代科学家：（1）使用信息学方法来识别作为药物靶向候选的生物分子，（2）使用结构基因组学、化学信息学和基于结构的设计来开发化学家族以靶向选定的生物分子和结构，以及(3) 在生物测试之前，使用 ADMET（吸收、分布、代谢、消除和毒性）分析和功效计算预测来选择可行的候选药物。培训将强调实现这些目标的计算机方法。机构间培训将由来自墨西哥湾沿岸联盟六个机构（贝勒医学院、医学博士、医学博士）的 63 名培训教员进行。 安德森癌症中心、莱斯大学、休斯顿大学、德克萨斯大学休斯顿健康科学中心和德克萨斯大学加尔维斯顿医学分部）位于休斯顿-加尔维斯顿地区，并将利用联合导师的研究培训、教学课程、研讨会、务虚会和职业发展活动。博士前培训生将在其所在机构注册并获得第一年的支持，并将在研究生培训的第 2-4 年竞争性基础上发放津贴。 所在机构将授予博士学位。博士后培训生将获得最多两年的支持。拟议的计划旨在培训药物发现研究的未来领导者。