Asthma Clinical Research Network Center at UCSF

加州大学旧金山分校哮喘临床研究网络中心

• 批准号: 7110277
• 负责人: Homer A Boushey
• 金额: $ 66.96万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7110277
• 关键词: asthma; beta adrenergic agent; clinical research; clinical trials; combination therapy; cooperative study; corticosteroids; human therapy evaluation; information display; inhalation drug administration; macrolide antibiotics; microarray technology; patient care management; patient oriented research; pharmacokinetics; respiratory disorder chemotherapy; respiratory infections

DESCRIPTION (provided by applicant): Investigators at the University of California, San Francisco here apply to participate in a cooperative research network examining current and novel therapies and management strategies for adult asthma and disseminating its findings to the medical community. The need for this network is demonstrated by asthma's rising morbidity and cost, by advances in basic research on its pathogenesis, and by the development of potentially effective but also potentially costly new therapies. Defining the place of these therapies will require large collaborative, multi-center studies. This application proposes two studies that address issues of current clinical importance and that incorporate new approaches to examining mechanisms of disease. The first project examines whether the effects of an inhaled corticosteroid on "airway remodeling" are dose-dependent, whether they are enhanced by the addition of a long-acting beta-agonist, and whether changes in measures of remodeling are related to changes in the levels of expression of genes for products thought to regulate collagen deposition and mucus production. The new technologies used in this study include design-based stereology for quantitative morphometry of bronchial biopsies and transcription profiling of gene expression in bronchial epithelial cells. The second project examines whether the addition of a macrolide antibiotic to usual care alters important outcomes in asthma exacerbations, especially in the subgroups currently most often treated, like those with purulent sputum or symptoms of sinusitis. This study will offer an opportunity to examine the validity of a microarray-based approach to detecting respiratory pathogens, developed in the UCSF Department of Biochemistry/Biophysics. To conduct these and other Asthma Clinical Research Network studies, we propose to draw from an established database of > 5000 patients with asthma who have participated in - or expressed an interest in participating in - clinical trials. Finally, we propose a Clinical Research Skills Development program for new appointees to the Pulmonary and Allergy Divisions, to foster their skills in clinical research and in genomic-based technologies.

描述（由申请人提供）： 加州大学旧金山分校的研究人员在这里申请参加合作研究网络，研究成人哮喘的当前和新型疗法和管理策略，并将其发现传播给医学界。哮喘的发病率和成本的上升，基础研究的发展以及发展潜在有效但可能成本昂贵的新疗法的发展，这表明了对该网络的需求。定义这些疗法的位置将需要大型协作，多中心研究。 该申请提出了两项​​研究，以解决当前临床重要性问题，并结合了检查疾病机制的新方法。第一个项目研究了吸入的皮质类固醇对“气道重塑”的影响是否依赖于剂量，是否通过添加长效β激动剂来增强它们，以及重塑的度量的变化是否与被认为是指调节胶原沉积和粘液核生产的基因表达水平的变化有关。本研究中使用的新技术包括基于设计的立体学用于支气管活检的定量形态计量学以及支气管上皮细胞中基因表达的转录分析。第二个项目研究了在通常的护理中添加大花环抗生素是否会改变哮喘加重的重要结果，尤其是在目前经常接受的亚组中，例如那些脓性痰或鼻窦炎症状。这项研究将提供一个机会，以检查基于微阵列的方法检测呼吸道病原体的有效性，该方法在UCSF生物化学/生物物理学系中开发。为了进行这些和其他哮喘临床研究网络研究，我们建议从已建立的数据库中汲取5000例哮喘患者的数据库，这些患者参加了 - 或表达参与 - 参与临床试验的兴趣。 最后，我们为肺部和过敏部门提出了一项针对新任命的临床研究技能开发计划，以促进其在临床研究和基于基因组技术方面的技能。